Transcription Factor
| Accessions: | 5cbx_B (3D-footprint 20231221), 5cbx_F (3D-footprint 20231221) |
| Names: | AncGR DNA Binding Domain, GCR_HUMAN, Glucocorticoid receptor, Nuclear receptor subfamily 3 group C member 1 |
| Organisms: | Homo sapiens |
| Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Uniprot: | P04150 |
| Length: | 74 |
| Pfam Domains: | 4-71 Zinc finger, C4 type (two domains) |
| Sequence: (in bold interface residues) | 1 PPKICLVCGDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPAC 60 61 RFRKCLQAGMNLEA |
| Interface Residues: | 13, 14, 16, 17, 23, 24, 26, 27, 30, 31, 55 |
| 3D-footprint Homologues: | 6fbq_A, 7wnh_D, 6l6q_B, 3g9m_B, 1a6y_A, 1lo1_A, 4oln_B, 2han_A, 1hcq_E, 8hbm_B, 5krb_G, 2han_B, 1kb2_B, 2a66_A, 2nll_B, 1lat_A, 7xv6_B, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 8cef_H, 4iqr_B, 7prw_B, 5cbx_B, 3g6t_A, 1r4i_A, 5cbz_E, 4tnt_B, 5e69_A, 4hn5_B, 5emc_A |
| Binding Motifs: | 5cbx_AB GnnCAnnnTGTnC 5cbx_EF GnrCAnnnTGtna |
| Binding Sites: | 5cbx_C / 5cbx_H 5cbx_D / 5cbx_G |
| Publications: | Hudson WH, Kossmann BR, de Vera IM, Chuo SW, Weikum ER, Eick GN, Thornton JW, Ivanov IN, Kojetin DJ, Ortlund EA. Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space. Proc Natl Acad Sci U S A 113:326-31 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.