Transcription Factor
| Accessions: | T109454_1.02 (CISBP 1.02), Q9LU92 (JASPAR 2024), T11979 (AthalianaCistrome v4_May2016) |
| Names: | AT3G25990, T109454_1.02;, TGT4_ARATH, Trihelix DNA-binding protein GT-4, Trihelix transcription factor GT-4, T11979; |
| Organisms: | Arabidopsis thaliana |
| Libraries: | CISBP 1.02 1, JASPAR 2024 2, AthalianaCistrome v4_May2016 3 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] 3 O'Malley RC, Huang SS, Song L, Lewsey MG, Bartlett A, Nery JR, Galli M, Gallavotti A, Ecker JR. Cistrome and Epicistrome Features Shape the Regulatory DNA Landscape. Cell 165:1280-92 (2016). [Pubmed] |
| Notes: | experiment type:PBM, family:MADF, ecotype:Col-0, experiment type: ampDAP-seq, experiment type: ampDAP-seq (methyl-cytosines removed by PCR), experiment type: DAP-seq, family:Trihelix |
| Length: | 372 |
| Pfam Domains: | 51-120 Myb/SANT-like DNA-binding domain 54-140 Myb/SANT-like DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MFVSDNNNPSRDINMMIGDVTSNGDLQPHQIILGESSGGEDHEIIKAPKKRAETWAQDET 60 61 RTLISLRREMDNLFNTSKSNKHLWEQISKKMREKGFDRSPSMCTDKWRNILKEFKKAKQH 120 121 EDKATSGGSTKMSYYNEIEDIFRERKKKVAFYKSPATTTPSSAKVDSFMQFTDKGFEDTG 180 181 ISFTSVEANGRPTLNLETELDHDGLPLPIAADPITANGVPPWNWRDTPGNGVDGQPFAGR 240 241 IITVKFGDYTRRVGIDGTAEAIKEAIRSAFRLRTRRAFWLEDEEQVIRSLDRDMPLGNYI 300 301 LRIDEGIAVRVCHYDESDPLPVHQEEKIFYTEEDYRDFLARRGWTCLREFDAFQNIDNMD 360 361 ELQSGRLYRGMR |
| Interface Residues: | 101, 104, 105, 106, 108, 109, 132, 170, 171, 188, 191, 193 |
| 3D-footprint Homologues: | 5eyb_B, 3hqg_A, 5u0a_E, 6c66_C, 7s03_A, 7k30_A |
| Binding Motifs: | M1277_1.02 ytaACymras M0789 / MA1368.1 AACCATGGTTAAawywtaacm M0778 wttTaAcyatRGTTArgktw MA1368.2 wtTAACYATGGTTa MA1368.3 TAACYATGGTTa |
| Binding Sites: | MA1368.2.1 MA1368.2.10 MA1368.2.11 MA1368.2.12 MA1368.2.13 MA1368.2.14 MA1368.2.15 / MA1368.2.8 MA1368.2.16 MA1368.2.17 / MA1368.2.9 MA1368.2.10 / MA1368.2.18 MA1368.2.19 MA1368.2.2 MA1368.2.20 MA1368.2.3 MA1368.2.4 MA1368.2.5 MA1368.2.5 / MA1368.2.6 MA1368.2.6 / MA1368.2.7 MA1368.2.16 / MA1368.2.7 / MA1368.2.8 MA1368.2.9 MA1368.2.11 MA1368.2.12 MA1368.2.13 MA1368.2.14 MA1368.2.15 MA1368.2.17 MA1368.2.18 MA1368.2.19 MA1368.2.20 MA1368.3.1 MA1368.3.10 MA1368.3.11 / MA1368.3.19 MA1368.3.12 / MA1368.3.20 MA1368.3.13 MA1368.3.14 MA1368.3.15 MA1368.3.16 / MA1368.3.7 MA1368.3.17 MA1368.3.18 MA1368.3.2 MA1368.3.3 MA1368.3.4 MA1368.3.5 MA1368.3.6 MA1368.3.8 MA1368.3.9 |
| Publications: | Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] Nagata T, Niyada E, Fujimoto N, Nagasaki Y, Noto K, Miyanoiri Y, Murata J, Hiratsuka K, Katahira M. Solution structures of the trihelix DNA-binding domains of the wild-type and a phosphomimetic mutant of Arabidopsis GT-1: mechanism for an increase in DNA-binding affinity through phosphorylation. Proteins 78:3033-47 (2010). [Pubmed] |
| Related annotations: | PaperBLAST |
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