Transcription Factor

						

			
Accessions: EN1 (SMILE-seq 1.0)

			
Names: EN1, HME1_HUMAN, Homeobox protein en-1, Homeobox protein engrailed-1, Hu-En-1
Organisms: Homo sapiens
Libraries: SMILE-seq 1.0 1
1 Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed]
Uniprot: Q05925
Notes: TF family: homeodomain
Length: 391
Pfam Domains:   304-360 Homeobox domain
  361-391 Engrailed homeobox C-terminal signature domain
Sequence: 
(in bold interface residues)		   1 MEEQQPEPKSQRDSALGAAAAATPGGLSLSLSPGASGSSGSGSDGDSVPVSPQPAPPSPP   60
  61 AAPCLPPLAHHPHLPPHPPPPPPQHLAAPAHQPQPAAQLHRTTNFFIDNILRPDFGCKKE  120
 121 QPPPQLLVAAAARGGAGGGGRVERDRGQTAAGRDPVHPLGTRAPGAASLLCAPDANCGPP  180
 181 DGSQPAAAGAGASKAGNPAAAAAAAAAAVAAAAAAAAAKPSDTGGGGSGGGAGSPGAQGT  240
 241 KYPEHGNPAILLMGSANGGPVVKTDSQQPLVWPAWVYCTRYSDRPSSGPRTRKLKKKKNE  300
 301 KEDKRPRTAFTAEQLQRLKAEFQANRYITEQRRQTLAQELSLNESQIKIWFQNKRAKIKK  360
 361 ATGIKNGLALHLMAQGLYNHSTTTVQDKDES
Interface Residues: 291, 304, 305, 306, 307, 345, 346, 348, 349, 352, 353, 356, 357, 360
3D-footprint Homologues: 5zfz_A, 1ig7_A, 6fqp_B, 1puf_A, 2h1k_B, 6a8r_A, 3cmy_A, 1fjl_B, 3d1n_M, 3lnq_A, 1jgg_B, 2lkx_A, 1nk2_P, 6m3d_C, 1zq3_P, 2ld5_A, 2hos_A, 7psx_B, 4j19_B, 2d5v_B, 5flv_I, 7q3o_C, 5zjt_E, 3a01_E, 5hod_A, 3rkq_B, 1puf_B, 1au7_A, 2hdd_A, 5jlw_D, 4cyc_A, 2r5y_A, 6es3_K, 1b72_A, 4xrs_G, 2xsd_C, 1e3o_C, 7xrc_C, 1le8_A, 1o4x_A, 1le8_B, 1du0_A, 4qtr_D, 1mnm_C, 6fqq_E, 1k61_B, 4xrm_B, 8g87_X
Binding Motifs: EN1 ryyAATTA
			
Publications: Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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