Transcription Factor

Accessions: UP00012A (UniPROBE 20160601)
Names: Bbx, bobby sox homolog (Drosophila), Hbp2, HMG box transcription factor BBX, HMG box-containing protein 2
Organisms: Mus musculus
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Uniprot: Q8VBW5
Description: bobby sox homolog (Drosophila)
Length: 101
Pfam Domains: 16-78 Domain of unknown function (DUF1898)
18-85 HMG (high mobility group) box
Sequence:
(in bold interface residues)
1 EQDVAETEDDESPEQRARRPMNAFLLFCKRHRSLVRQEHPRLDNRGATKILADWWAVLDP 60
61 KEKQKYTDMAKEYKDAFMKANPGYRWCPTTNKPVKSPTPTV
Interface Residues: 19, 22, 24, 25, 28, 32, 35, 43, 44, 45, 46, 48, 86, 88, 92
3D-footprint Homologues: 3f27_D, 6jrp_D, 1qrv_A, 3u2b_C, 7m5w_A, 2gzk_A, 4s2q_D, 1j5n_A, 2lef_A, 4y60_C, 1o4x_B, 1hry_A, 1ckt_A, 7zie_A
Binding Motifs: UP00012A_1 taaTTCAwTGAAswd
UP00012A_2 tvwybGTTAACaswkrr
Binding Sites: AAATGAAC
AATGAATG
AATGAATT
AATTAATA
ATCAATTA
ATGAATGA
ATGAATGG
ATGAATTA
ATTCATTC
GAAATGAA
TAAATGAA
TCAATGAA
TCAATTGA
TCACTGAA
TCTTTTAA
TGAATGAA
TGTATTAA
TTAATAAA
TTAATTAA
TTCATGAA
Publications: Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed]
Related annotations: PaperBLAST

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