Transcription Factor

						

			
Accessions: ZNF675 (humanC2H2ZF-ChIP Feb2015), Q8TD23 (JASPAR 2024)

			
Names: ENSG00000197372, Q8TD23, ZNF675, TRAF6-binding zinc finger protein, TRAF6-inhibitory zinc finger protein, Zinc finger protein 675, ZN675_HUMAN
Organisms: Homo sapiens
Libraries: humanC2H2ZF-ChIP Feb2015 1, JASPAR 2024 2
1 Najafabadi HS, Mnaimneh S, Schmitges FW, Garton M, Lam KN, Yang A, Albu M, Weirauch MT, Radovani E, Kim PM, Greenblatt J, Frey BJ, Hughes TR. C2H2 zinc finger proteins greatly expand the human regulatory lexicon. Nat Biotechnol 33:555-62 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: TF family: C2H2;KRAB experiment: ChIP-seq/MEME/B1H-RC
Length: 568
Pfam Domains:      4-44 KRAB box
  160-181 Zinc-finger double domain
  172-192 Zinc finger, C2H2 type
  172-194 C2H2-type zinc finger
  215-238 Zinc-finger double domain
  227-244 C2H2-type zinc finger
  249-266 Zinc-finger double domain
  255-275 C2H2-type zinc finger
  256-278 Zinc finger, C2H2 type
  256-278 C2H2-type zinc finger
  270-294 Zinc-finger double domain
  283-304 C2H2-type zinc finger
  284-306 Zinc finger, C2H2 type
  284-306 C2H2-type zinc finger
  298-323 Zinc-finger double domain
  312-332 C2H2-type zinc finger
  312-334 Zinc finger, C2H2 type
  312-334 C2H2-type zinc finger
  327-350 Zinc-finger double domain
  339-359 C2H2-type zinc finger
  340-362 Zinc finger, C2H2 type
  340-360 C2H2-type zinc finger
  355-378 Zinc-finger double domain
  367-388 C2H2-type zinc finger
  368-390 Zinc finger, C2H2 type
  368-390 C2H2-type zinc finger
  382-407 Zinc-finger double domain
  395-416 C2H2-type zinc finger
  396-418 Zinc finger, C2H2 type
  396-418 C2H2-type zinc finger
  410-434 Zinc-finger double domain
  423-446 C2H2-type zinc finger
  424-446 C2H2-type zinc finger
  424-446 Zinc finger, C2H2 type
  439-461 Zinc-finger double domain
  451-472 C2H2-type zinc finger
  452-474 Zinc finger, C2H2 type
  467-491 Zinc-finger double domain
  479-500 C2H2-type zinc finger
  480-502 C2H2-type zinc finger
  480-502 Zinc finger, C2H2 type
  494-519 Zinc-finger double domain
  507-527 C2H2-type zinc finger
  508-530 C2H2-type zinc finger
  508-530 Zinc finger, C2H2 type
  523-546 Zinc-finger double domain
  535-556 C2H2-type zinc finger
  536-558 C2H2-type zinc finger
  536-558 Zinc finger, C2H2 type
Sequence: 
(in bold interface residues)		   1 MGLLTFRDVAIEFSLEEWQCLDTAQRNLYKNVILENYRNLVFLGIAVSKQDLITCLEQEK   60
  61 EPLTVKRHEMVNEPPVMCSHFAQEFWPEQNIKDSFEKVTLRRYEKCGNDNFQLKGCKSVD  120
 121 ECKLHKGGYNGLNQCLPTMQSKMFQCDKYVKVFNKFSHSDRHKIKHMENKPFKCKECGRS  180
 181 FCMLSHLTRHERNYTKVNFCKCEECEKAVNQSSKLTKHKRIYTCEKLYKCQECDRTFNQF  240
 241 SNLTEYKKDYAREKPYKCEECGKAFNQSSHLTTHKIIHTGEKPYKCEECGKAFNQFSNLT  300
 301 THKKIHTGEQPYICEECGKAFTQSSTLTTHKRIHTGEKPYKCEECGKAFNRSSKLTEHKN  360
 361 IHTGEQPYKCEECGKAFNRSSNLTEHRKIHTEEKPYKCKECGKAFKHSSALTTHKRIHTG  420
 421 EKPYKCEECGKAFNRSSKLTEHKKLHTGKKPYKCEECGKAFIQSSKLTEHKKIHSGEIPY  480
 481 KCEECGKAFKHSSSLTTHKRIHTGEKPYKCEECGKAFSRSSKLTEHKIIHTGEKPYKCER  540
 541 CDKAFNQSANLTKHKKIHTGEKLQNWNV
Interface Residues: 239, 241, 245, 256, 266, 267, 268, 269, 270, 273, 277, 294, 295, 296, 297, 298, 300, 301, 303, 304, 305, 307, 322, 323, 324, 325, 326, 328, 329, 350, 351, 352, 353, 354, 356, 357, 378, 379, 380, 381, 382, 385, 387, 406, 407, 408, 409, 410, 413, 414, 416, 434, 435, 436, 437, 438, 439, 440, 441, 442, 445, 447, 461, 462, 463, 464, 465, 466, 469, 473, 490, 491, 492, 493, 494, 496, 497, 519, 520, 521, 522, 524, 525, 546, 547, 549, 550, 553
3D-footprint Homologues: 7w1m_H, 2kmk_A, 6wmi_A, 8ssq_A, 8ssu_A, 2i13_A, 5ei9_F, 6e94_A, 5k5i_A, 1g2f_F, 6ml4_A, 1mey_C, 5kl3_A, 7y3m_I, 2jpa_A, 1tf6_A, 5v3j_F, 7txc_E, 2lt7_A, 5yel_A, 7n5w_A, 1f2i_J, 5yj3_D, 2wbs_A, 7eyi_G, 6jnm_A, 4x9j_A, 7ysf_A, 6a57_A, 8cuc_F, 7y3l_A, 5und_A, 2gli_A, 1llm_D, 6blw_A, 4m9v_C, 8h9h_G, 5kkq_D, 1ubd_C, 1tf3_A, 3uk3_C, 2drp_D, 8gn3_A, 6u9q_A, 5k5l_F
Binding Motifs: ZNF675_ChIP GGATTArGAGGACA
UN0212.1 GraAAAATGgTTT
MA1714.1 rgGmyyarGAGGmcAaAATGw
MA1714.2 gGmyyarGAGGmcAaAATG
Binding Sites: UN0212.1.1
UN0212.1.10
UN0212.1.11
UN0212.1.12
UN0212.1.13
UN0212.1.14
UN0212.1.15
UN0212.1.16
UN0212.1.17
UN0212.1.18
UN0212.1.19
UN0212.1.2
UN0212.1.20
UN0212.1.3
UN0212.1.4
UN0212.1.5
UN0212.1.6
UN0212.1.7
UN0212.1.8
UN0212.1.9
			
Publications: Dinh DT, Breen J, Akison LK, DeMayo FJ, Brown HM, Robker RL, Russell DL. Tissue-specific progesterone receptor-chromatin binding and the regulation of progesterone-dependent gene expression. Sci Rep 9:11966 (2019). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.