Transcription Factor

Accessions: GATA1_TF1 (HumanTF2 1.0), GATA1 (HT-SELEX2 May2017)
Names: Eryf1, Erythroid transcription factor, GATA-1, GATA-binding factor 1, GATA1, GATA1_HUMAN, GF-1, NF-E1 DNA-binding protein, ENSG00000102145
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, HT-SELEX2 May2017 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]
Uniprot: P15976
Notes: Ensembl ID: ENSG00000102145; Construct type: TF1(SBP); TF family: znfGATA; Clone source: Megaman, TF family: Znf_GATA experiment: HT-SELEX Hamming distance: 1 cycle: 4b0, TF family: Znf_GATA experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4b0
Length: 143
Pfam Domains: 25-58 GATA zinc finger
79-112 GATA zinc finger
Sequence:
(in bold interface residues)
1 LNSAAYSSPKLRGTLPLPPCEARECVNCGATATPLWRRDRTGHYLCNACGLYHKMNGQNR 60
61 PLIRPKKRLIVSKRAGTQCTNCQTTTTTLWRRNASGDPVCNACGLYYKLHQVNRPLTMRK 120
121 DGIQTRNRKASGKGKKKRGSSLG
Interface Residues: 34, 35, 37, 47, 51, 88, 89, 91, 101, 105, 106, 109, 126, 128, 129
3D-footprint Homologues: 4hc9_A, 3vd6_C, 1gat_A, 3dfx_B, 4gat_A
Binding Motifs: GATA1 hGATAAs
GATA1_2 GATAAkrrcmTTATC
GATA1_methyl_1 GATAAkrwymTTATC
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Related annotations: PaperBLAST

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