Transcription Factor

						

			
Accessions: XBP1_HUMAN (HOCOMOCO 10), P17861 (JASPAR 2024)

			
Names: Tax-responsive element-binding protein 5, TREB-5, X-box-binding protein 1, XBP-1, XBP1_HUMAN
Organisms: Homo sapiens
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 261
Pfam Domains:    69-120 Basic region leucine zipper
   70-126 bZIP transcription factor
Sequence: 
(in bold interface residues)		   1 MVVVAAAPNPADGTPKVLLLSGQPASAAGAPAGQALPLMVPAQRGASPEAASGGLPQARK   60
  61 RQRLTHLSPEEKALRRKLKNRVAAQTARDRKKARMSELEQQVVDLEEENQKLLLENQLLR  120
 121 EKTHGLVVENQELRQRLGMDALVAEEEAEAKGNEVRPVAGSAESAALRLRAPLQQVQAQL  180
 181 SPLQNISPWILAVLTLQIQSLISCWAFWTTWTQSCSSNALPQSLPAWRSSQRSTQKDPVP  240
 241 YQPPFLCQWGRHQPSWKPLMN
Interface Residues: 76, 79, 80, 81, 83, 84, 87, 88, 91
3D-footprint Homologues: 7x5e_E, 7x5e_F, 1gd2_G, 1skn_P, 6mg1_B, 2wt7_A, 1dh3_C, 5t01_B, 5vpe_D
Binding Motifs: MA0844.1 wrkGmCACGTCAkc
XBP1_HUMAN.H10MO.C|M01601 GACGTGkCmtww
MA0844.2 GmCACGTCAkc
			
Publications: Yamamoto K, Yoshida H, Kokame K, Kaufman RJ, Mori K. Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II. J Biochem 136:343-50 (2004). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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