Transcription Factor

						

			
Accessions: P80205 (JASPAR 2024)

			
Names: Homeobox protein OTX1, Orthodenticle homolog 1, OTX1_MOUSE
Organisms: Mus musculus
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 355
Pfam Domains:     39-95 Homeobox domain
  178-280 Otx1 transcription factor
Sequence: 
(in bold interface residues)		   1 MMSYLKQPPYGMNGLGLAGPAMDLLHPSVGYPATPRKQRRERTTFTRSQLDVLEALFAKT   60
  61 RYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQSGNGTKTRPVKKKSSPVRESSG  120
 121 SESSGQFTPPAVSSSASSSSSASSASANPAAAAAAGLGGNPVAAASSLSTPTASSIWSPA  180
 181 SISPGSAPTSVSVPEPLAAPSNASCMQRSVAAGAATAAASYPMSYGQGGSYGQGYPAPSS  240
 241 SYFGGVDCSSYLAPMHSHHHPHQLSPMAPSSMAGHHHHHPHAHHPLSQSSGHHHHHHHHH  300
 301 HHQGYGGSGLAFNSADCLDYKEPAAAAASSAWKLNFNSPDCLDYKDQASWRFQVL
Interface Residues: 38, 39, 40, 41, 42, 80, 81, 83, 84, 87, 88, 91, 92, 95
3D-footprint Homologues: 4j19_B, 1ig7_A, 6a8r_A, 3cmy_A, 2h1k_B, 1puf_A, 3d1n_M, 5zfz_A, 1fjl_B, 1nk2_P, 1zq3_P, 3lnq_A, 1jgg_B, 2lkx_A, 6m3d_C, 2ld5_A, 7q3o_C, 6es3_K, 5flv_I, 3l1p_A, 2hos_A, 1b72_A, 5zjt_E, 3a01_E, 7psx_B, 5hod_A, 5jlw_D, 3rkq_B, 4xrs_G, 2hdd_A, 1au7_A, 4cyc_A, 2r5y_A, 1puf_B, 1e3o_C, 1le8_A, 1o4x_A, 1du0_A, 4qtr_D, 8g87_X
Binding Motifs: PH0129.1 dgwrgGGATTAAtwtwy
			
Publications: Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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