Transcription Factor

Accessions: CDX4 (HT-SELEX2 May2017), O14627 (JASPAR 2024)
Names: CDX4, ENSG00000131264, Caudal-type homeobox protein 4, CDX4_HUMAN, Homeobox protein CDX-4
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, JASPAR 2024 2
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: TF family: Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3
Length: 284
Pfam Domains: 13-171 Caudal like protein activation region
175-230 Homeobox domain
Sequence:
(in bold interface residues)
1 MYGSCLLEKEAGMYPGTLMSPGGDGTAGTGGTGGGGSPMPASNFAAAPAFSHYMGYPHMP 60
61 SMDPHWPSLGVWGSPYSPPREDWSVYPGPSSTMGTVPVNDVTSSPAAFCSTDYSNLGPVG 120
121 GGTSGSSLPGQAGGSLVPTDAGAAKASSPSRSRHSPYAWMRKTVQVTGKTRTKEKYRVVY 180
181 TDHQRLELEKEFHCNRYITIQRKSELAVNLGLSERQVKIWFQNRRAKERKMIKKKISQFE 240
241 NSGGSVQSDSDSISPGELPNTFFTTPSAVRGFQPIEIQQVIVSE
Interface Residues: 171, 174, 175, 176, 177, 215, 216, 218, 219, 222, 223, 226, 227, 229, 230
3D-footprint Homologues: 3l1p_A, 2h1k_B, 1puf_A, 3cmy_A, 3d1n_M, 1fjl_B, 3lnq_A, 2lkx_A, 1jgg_B, 1nk2_P, 1zq3_P, 2ld5_A, 6es3_K, 7q3o_C, 1ig7_A, 5zjt_E, 3a01_E, 6a8r_A, 2hdd_A, 7psx_B, 5jlw_D, 3rkq_B, 2r5y_A, 4xrs_G, 2hos_A, 5zfz_A, 4cyc_A, 6m3d_C, 1b72_A, 5flv_I, 7xrc_C, 1e3o_C, 1au7_A, 2xsd_C, 1le8_A, 1o4x_A, 4qtr_D, 1le8_B, 6wig_A, 1du0_A, 5hod_A, 8g87_X, 4xrm_B, 1mnm_C, 1puf_B, 1k61_B
Binding Motifs: CDX4_3 / MA1473.1 gGymATAAAac
CDX4_methyl_1 sGTCGTAAAas
CDX4_methyl_2 kGCmATAAAac
MA1473.2 GymATAAAa
Publications: Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]
Related annotations: PaperBLAST

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