Transcription Factor
| Accessions: | RFX3_HUMAN (HOCOMOCO 10), P48380 (JASPAR 2024) |
| Names: | Regulatory factor X 3, RFX3_HUMAN, Transcription factor RFX3 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P48380 |
| Length: | 749 |
| Pfam Domains: | 1-139 RFX1 transcription activation region 183-248 RFX DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MQTSETGSDTGSTVTLQTSVASQAAVPTQVVQQVPVQQQVQQVQTVQQVQHVYPAQVQYV 60 61 EGSDTVYTNGAIRTTTYPYTETQMYSQNTGGNYFDTQGSSAQVTTVVSSHSMVGTGGIQM 120 121 GVTGGQLISSSGGTYLIGNSMENSGHSVTHTTRASPATIEMAIETLQKSDGLSTHRSSLL 180 181 NSHLQWLLDNYETAEGVSLPRSTLYNHYLRHCQEHKLDPVNAASFGKLIRSIFMGLRTRR 240 241 LGTRGNSKYHYYGIRVKPDSPLNRLQEDMQYMAMRQQPMQQKQRYKPMQKVDGVADGFTG 300 301 SGQQTGTSVEQTVIAQSQHHQQFLDASRALPEFGEVEISSLPDGTTFEDIKSLQSLYREH 360 361 CEAILDVVVNLQFSLIEKLWQTFWRYSPSTPTDGTTITESSNLSEIESRLPKAKLITLCK 420 421 HESILKWMCNCDHGMYQALVEILIPDVLRPIPSALTQAIRNFAKSLEGWLSNAMNNIPQR 480 481 MIQTKVAAVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASW 540 541 VCQCDDNMVQRLETDFKMTLQQQSTLEQWAAWLDNVMMQALKPYEGRPSFPKAARQFLLK 600 601 WSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAQATGETPIAVMGEFGDL 660 661 NAVSPGNLDKDEGSEVESEMDEELDDSSEPQAKREKTELSQAFPVGCMQPVLETGVQPSL 720 721 LNPIHSEHIVTSTQTIRQCSATGNTYTAV |
| Interface Residues: | 223, 227, 240, 244, 249 |
| 3D-footprint Homologues: | 1dp7_P |
| Binding Motifs: | MA0798.1 sGTTrCCATGGyAACs RFX3_HUMAN.H10MO.B|M01483 sGTTrCCATGGyra MA0798.2 ykGTTGCyATGGcr MA0798.3 sGTTrCCATGGCAACs |
| Binding Sites: | MA0798.2.1 MA0798.2.2 MA0798.2.3 MA0798.2.4 MA0798.2.10 MA0798.2.11 MA0798.2.12 MA0798.2.13 MA0798.2.14 MA0798.2.15 MA0798.2.16 MA0798.2.17 MA0798.2.18 MA0798.2.19 MA0798.2.20 MA0798.2.5 / MA0798.2.6 MA0798.2.7 MA0798.2.8 MA0798.2.9 |
| Publications: | Emery P., Strubin M., Hofmann K., Bucher P., Mach B., Reith W. A consensus motif in the RFX DNA binding domain and binding domain mutants with altered specificity. Mol. Cell. Biol. 16:4486-4494 (1996). [Pubmed] Jolma A., Kivioja T., Toivonen J., Cheng L., Wei G., Enge M., Taipale M., Vaquerizas J. M., Yan J., Sillanpaa M. J., Bonke M., Palin K., Talukder S., Hughes T. R., Luscombe N. M., Ukkonen E., Taipale J. Multiplexed massively parallel SELEX for characterization of human transcription factor binding specificities.. Genome Res. 20:861-873 (2010). [Pubmed] |
| Related annotations: | PaperBLAST |
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