Transcription Factor

						

			
Accessions: 5k5h_A (3D-footprint 20231221)

			
Names: 11-zinc finger protein, CCCTC-binding factor, CTCF_HUMAN, CTCFL paralog, Transcriptional repressor CTCF
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P49711
Length: 111
Pfam Domains:      2-24 C2H2-type zinc finger
     2-24 C2H2-type zinc-finger domain
    17-38 Zinc-finger double domain
    30-52 C2H2-type zinc finger
    30-52 Zinc finger, C2H2 type
    30-53 C2H2-type zinc-finger domain
    45-69 Zinc-finger double domain
    58-81 C2H2-type zinc finger
   88-111 C2H2-type zinc finger
   88-111 Zinc finger, C2H2 type
Sequence: 
(in bold interface residues)		   1 PFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHSGEKPYEC   60
  61 YICHARFTQSGTMKMHILQKHTENVAKFHCPHCDTVIARKSDLGVHLRKQH
Interface Residues: 2, 12, 13, 14, 15, 16, 18, 19, 20, 21, 22, 25, 40, 41, 42, 43, 44, 45, 46, 47, 48, 55, 68, 69, 70, 71, 72, 74, 75, 79, 99, 100, 101, 102, 105, 108
3D-footprint Homologues: 2kmk_A, 7y3l_A, 5v3j_F, 7n5w_A, 1tf3_A, 1g2f_F, 6wmi_A, 8ssq_A, 1tf6_A, 7w1m_H, 5und_A, 2gli_A, 8ssu_A, 1ubd_C, 6ml4_A, 4x9j_A, 1mey_C, 6blw_A, 5kkq_D, 1f2i_J, 6u9q_A, 5ei9_F, 5kl3_A, 7ysf_A, 4m9v_C, 7eyi_G, 8h9h_G, 2lt7_A, 2i13_A, 6e94_A, 2jpa_A, 8cuc_F, 3uk3_C, 5yj3_D, 5k5i_A, 6jnm_A, 1llm_D, 6a57_A, 8gn3_A, 2wbs_A, 7txc_E, 7y3m_I, 1yuj_A, 2drp_D, 5yel_A, 5k5l_F
Binding Motifs: 5k5h_A CGCCCCCTGCcG
Binding Sites: 5k5h_B
5k5h_C
			
Publications: Hashimoto H, Wang D, Horton JR, Zhang X, Corces VG, Cheng X. Structural Basis for the Versatile and Methylation-Dependent Binding of CTCF to DNA. Mol Cell 66:711-720 (2017). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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