Transcription Factor
| Accessions: | SUH_HUMAN (HOCOMOCO 10), Q06330 (JASPAR 2024) |
| Names: | CBF-1, J kappa-recombination signal-binding protein, RBP-J kappa, RBP-JK, Recombining binding protein suppressor of hairless, Renal carcinoma antigen NY-REN-30, SUH_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q06330 |
| Length: | 500 |
| Pfam Domains: | 47-178 LAG1, DNA binding 179-328 Beta-trefoil DNA-binding domain 356-444 IPT/TIG domain |
| Sequence: (in bold interface residues) | 1 MDHTEGSPAEEPPAHAPSPGKFGERPPPKRLTREAMRNYLKERGDQTVLILHAKVAQKSY 60 61 GNEKRFFCPPPCVYLMGSGWKKKKEQMERDGCSEQESQPCAFIGIGNSDQEMQQLNLEGK 120 121 NYCTAKTLYISDSDKRKHFMLSVKMFYGNSDDIGVFLSKRIKVISKPSKKKQSLKNADLC 180 181 IASGTKVALFNRLRSQTVSTRYLHVEGGNFHASSQQWGAFFIHLLDDDESEGEEFTVRDG 240 241 YIHYGQTVKLVCSVTGMALPRLIIRKVDKQTALLDADDPVSQLHKCAFYLKDTERMYLCL 300 301 SQERIIQFQATPCPKEPNKEMINDGASWTIISTDKAEYTFYEGMGPVLAPVTPVPVVESL 360 361 QLNGGGDVAMLELTGQNFTPNLRVWFGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQ 420 421 PVQVPVTLVRNDGIIYSTSLTFTYTPEPGPRPHCSAAGAILRANSSQVPPNESNTNSEGS 480 481 YTNASTNSTSVTSSTATVVS |
| Interface Residues: | 60, 63, 65, 165, 166, 169, 194, 195, 196 |
| 3D-footprint Homologues: | 3iag_C, 5e24_E, 3brd_A |
| Binding Motifs: | SUH_HUMAN.H10MO.C|M01546 sygTGrGAAma MA1116.1 bsTGGGAAmg MA1116.2 TGGGAA |
| Binding Sites: | MA1116.1.1 MA1116.1.10 MA1116.1.11 MA1116.1.12 MA1116.1.13 MA1116.1.14 / MA1116.1.9 MA1116.1.15 MA1116.1.16 MA1116.1.17 MA1116.1.18 MA1116.1.19 MA1116.1.2 MA1116.1.20 MA1116.1.3 MA1116.1.4 MA1116.1.5 MA1116.1.6 MA1116.1.7 MA1116.1.8 MA1116.2.15 MA1116.2.1 / MA1116.2.11 / MA1116.2.12 / MA1116.2.13 / MA1116.2.14 / MA1116.2.16 / MA1116.2.17 / MA1116.2.18 / MA1116.2.19 / MA1116.2.2 / MA1116.2.20 / MA1116.2.3 / MA1116.2.4 / MA1116.2.8 / MA1116.2.9 MA1116.2.10 MA1116.2.5 MA1116.2.6 MA1116.2.7 |
| Publications: | Castel D, Mourikis P, Bartels SJ, Brinkman AB, Tajbakhsh S, Stunnenberg HG. Dynamic binding of RBPJ is determined by Notch signaling status. Genes Dev 27:1059-71 (2013). [Pubmed] |
| Related annotations: | PaperBLAST |
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