Transcription Factor

Accessions: UP00224A (UniPROBE 20160601), P26367 (JASPAR 2024), P63015 (JASPAR 2024)
Names: 1500038E17Rik, AEY11, Dey, Dickie's small eye, Gsfaey11, Oculorhombin, paired box gene 6, Paired box protein Pax-6, Pax6, Sey, Aniridia type II protein, PAX6_HUMAN, PAX6_MOUSE
Organisms: Mus musculus, Homo sapiens
Libraries: UniPROBE 20160601 1, JASPAR 2024 2
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Description: paired box gene 6
Length: 422
Pfam Domains: 4-128 'Paired box' domain
212-267 Homeobox domain
Sequence:
(in bold interface residues)
1 MQNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRY 60
61 YETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSV 120
121 SSINRVLRNLASEKQQMGADGMYDKLRMLNGQTGSWGTRPGWYPGTSVPGQPTQDGCQQQ 180
181 EGGGENTNSISSNGEDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFAR 240
241 ERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNTPSHIPISSSFSTSVYQPIP 300
301 QPTTPVSSFTSGSMLGRTDTALTNTYSALPPMPSFTMANNLPMQPPVPSQTSSYSCMLPT 360
361 SPSVNGRSYDTYTPPHMQTHMNSQPMGTSGTTSTGLISPGVSVPVQVPGSEPDMSQYWPR 420
421 LQ
Interface Residues: 17, 49, 50, 52, 54, 55, 71, 74, 77, 119, 120, 121, 122, 124, 125, 128, 190, 193, 194, 197, 211, 212, 213, 214, 252, 253, 255, 256, 259, 260, 263, 264, 266, 267, 270
3D-footprint Homologues: 1k78_A, 6pax_A, 1pdn_C, 5zfz_A, 1fjl_B, 1puf_A, 3cmy_A, 1ig7_A, 3d1n_M, 6a8r_A, 2h1k_B, 3lnq_A, 2lkx_A, 1nk2_P, 6m3d_C, 1jgg_B, 1zq3_P, 6es3_K, 7q3o_C, 2ld5_A, 7psx_B, 5jlw_D, 1b72_A, 4xrs_G, 2hdd_A, 3rkq_B, 2r5y_A, 1puf_B, 5flv_I, 2hos_A, 5zjt_E, 4cyc_A, 5hod_A, 3l1p_A, 1au7_A, 3a01_E, 1le8_A, 7xrc_C, 2xsd_C, 1e3o_C, 1mnm_C, 1du0_A, 1o4x_A, 1le8_B, 8g87_X, 1k61_B, 4qtr_D
Binding Motifs: UP00224A_1 TrayTAATTArtkvac
MA0069.1 TTyACGCwTsAvTk
PH0132.1 TrayTAATTArtkvac
Binding Sites: AAATTAAT
AATAATTA
AATTAATC
AATTAATG
AATTAATT
ACTAATTA
ATAATTAA
ATAATTAG
ATCAATTA
ATTAATTA
ATTAATTC
ATTAATTG
CCAATTAA
CTAATTAA
CTAATTAG
GATTAATC
GCTAATTA
GTTAATTA
TCAATTAA
TTAATTAA
MA0069.1.1
MA0069.1.10
MA0069.1.11
MA0069.1.12
MA0069.1.13
MA0069.1.14
MA0069.1.15
MA0069.1.16
MA0069.1.17
MA0069.1.18 / MA0069.1.19
MA0069.1.2 / MA0069.1.3 / MA0069.1.4 / MA0069.1.5
MA0069.1.20
MA0069.1.6 / MA0069.1.7 / MA0069.1.8 / MA0069.1.9
Publications: Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]

Epstein J., Cai J., Glaser T., Jepeal L., Maas R. Identification of a Pax paired domain recognition sequence and evidence for DNA-dependent conformational changes. J. Biol. Chem. 269:8355-8361 (1994). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.