Transcription Factor
Accessions: | RARA (SMILE-seq 1.0) |
Names: | cDNA, FLJ92939, Homo sapiens retinoic acid receptor, alpha (RARA, Q6I9R7_HUMAN, RARA, RARA protein, Retinoic acid nuclear receptor alpha variant 1, Retinoic acid receptor, alpha, isoform CRA_c |
Organisms: | Homo sapiens |
Libraries: | SMILE-seq 1.0 1 1 Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed] |
Uniprot: | Q6I9R7 |
Notes: | TF family: Nuclear Receptor |
Length: | 461 |
Pfam Domains: | 87-155 Zinc finger, C4 type (two domains) 221-394 Ligand-binding domain of nuclear hormone receptor |
Sequence: (in bold interface residues) | 1 MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPAT 60 61 IETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM 120 121 VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTL 180 181 TPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTV 240 241 EFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNA 300 301 GFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALK 360 361 VYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSGGL 420 421 DTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHS |
Interface Residues: | 96, 97, 99, 100, 106, 107, 109, 110, 113, 114, 138, 160, 162, 164, 167, 169 |
3D-footprint Homologues: | 6fbq_A, 7wnh_D, 6l6q_B, 3g9m_B, 1a6y_A, 1lo1_A, 4oln_B, 2han_B, 1kb2_B, 2a66_A, 2nll_B, 1lat_A, 7xv6_B, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 8cef_H, 4iqr_B, 2han_A, 1hcq_E, 8hbm_B, 5krb_G, 5cbz_E, 4tnt_B, 5e69_A, 4hn5_B, 5emc_A, 7prw_B, 5cbx_B, 3g6t_A, 1r4i_A |
Binding Motifs: | RARA rAGGTCA RARA_RXRA / RARA_RXRG rrGGTCAwgkarrGGtCA |
Publications: | Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed] |
Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.