Transcription Factor
| Accessions: | T105009_1.02 (CISBP 1.02), T105287_1.02 (CISBP 1.02), PIT1_MOUSE (HOCOMOCO 10), Q00286 (JASPAR 2024) |
| Names: | Pou1f1, T105009_1.02;, Pit1, T105287_1.02;, GHF-1, Growth hormone factor 1, PIT-1, PIT1_MOUSE, Pituitary-specific positive transcription factor 1 |
| Organisms: | Mus musculus |
| Libraries: | CISBP 1.02 1, HOCOMOCO 10 2, JASPAR 2024 3 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | experiment type:PBM, family:Homeodomain,POU |
| Length: | 291 |
| Pfam Domains: | 125-198 Pou domain - N-terminal to homeobox domain 215-271 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MSCQSFTSADTFITLNSDASAALPLRMHHSAAECLPASNHATNVMSTATGLHYSVPSCHY 60 61 GNQPSTYGVMAGSLTPCLYKFPDHTLSHGFPPLHQPLLAEDPAASEFKQELRRKSKLVEE 120 121 PIDMDSPEIRELEQFANEFKVRRIKLGYTQTNVGEALAAVHGSEFSQTTICRFENLQLSF 180 181 KNACKLKAILSKWLEEAEQVGALYNEKVGANERKRKRRTTISVAAKDALERHFGEHSKPS 240 241 SQEIMRMAEELNLEKEVVRVWFCNRRQREKRVKTSLNQSLFSISKEHLECR |
| Interface Residues: | 150, 166, 167, 168, 169, 171, 172, 174, 175, 178, 182, 215, 216, 217, 218, 256, 257, 259, 260, 263, 264, 267, 268, 271 |
| 3D-footprint Homologues: | 7u0g_M, 3d1n_M, 3l1p_A, 1o4x_A, 7xrc_C, 2xsd_C, 8g87_X, 1e3o_C, 1au7_A, 2d5v_B, 5zfz_A, 1ig7_A, 6fqp_B, 6a8r_A, 1fjl_B, 3cmy_A, 1nk2_P, 1zq3_P, 2lkx_A, 2ld5_A, 7q3o_C, 6es3_K, 2hdd_A, 1b72_A, 3rkq_B, 2r5y_A, 4xrs_G, 2hos_A, 1jgg_B, 5flv_I, 2h1k_B, 5hod_A, 3lnq_A, 1puf_B, 1le8_A, 1du0_A, 5zjt_E, 4cyc_A, 7psx_B, 1puf_A, 4qtr_D, 3a01_E, 4xrm_B |
| Binding Motifs: | M1233_1.02 waykmATwww M1243_1.02 wwtkmATwww PIT1_MOUSE.H10MO.C|M01288 ytmaTGaAWAWwy PH0142.1 rrwtAATTAATTAwgtc |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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