Transcription Factor
| Accessions: | Q8N9L1 (JASPAR 2024) |
| Names: | ZIC4_HUMAN, Zinc finger protein of the cerebellum 4, Zinc finger protein ZIC 4 |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q8N9L1 |
| Length: | 334 |
| Pfam Domains: | 143-162 C2H2-type zinc finger 191-216 Zinc-finger double domain 204-228 Zinc finger, C2H2 type 204-228 C2H2-type zinc finger 220-247 Zinc-finger double domain 234-258 C2H2-type zinc finger 264-288 C2H2-type zinc finger 264-288 Zinc finger, C2H2 type |
| Sequence: (in bold interface residues) | 1 MRYKTSLVMRKRLRLYRNTLKESSSSSGHHGPQLTAASSPSVFPGLHEEPPQASPSRPLN 60 61 GLLRLGLPGDMYARPEPFPPGPAARSDALAAAAALHGYGGMNLTVNLAAPHGPGAFFRYM 120 121 RQPIKQELICKWLAADGTATPSLCSKTFSTMHELVTHVTVEHVGGPEQANHICFWEECPR 180 181 QGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFRCEFEG 240 241 CERRFANSSDRKKHSHVHTSDKPYTCKVRGCDKCYTHPSSLRKHMKVHGRSPPPSSGYDS 300 301 ATPSALVSPSSDCGHKSQVASSAAVAARTADLSE |
| Interface Residues: | 149, 150, 152, 153, 156, 186, 187, 188, 189, 190, 192, 193, 195, 196, 197, 199, 216, 217, 218, 219, 220, 222, 223, 224, 225, 228, 229, 232, 246, 247, 248, 249, 250, 252, 253, 254, 257, 269, 277, 278, 279, 280, 281, 282, 283, 284 |
| 3D-footprint Homologues: | 5v3j_F, 1ubd_C, 1tf3_A, 7w1m_H, 8cuc_F, 7y3l_A, 7n5w_A, 4x9j_A, 5ei9_F, 2kmk_A, 8ssq_A, 2gli_A, 1g2f_F, 8ssu_A, 1tf6_A, 6ml4_A, 8gn3_A, 5kkq_D, 8h9h_G, 7eyi_G, 6e94_A, 7ysf_A, 6wmi_A, 5k5i_A, 2i13_A, 5und_A, 2jpa_A, 2lt7_A, 6jnm_A, 3uk3_C, 2v6e_B, 6u9q_A, 5yel_A, 1mey_C, 7txc_E, 5kl3_A, 2drp_D, 1f2i_J, 1llm_D, 6blw_A, 7y3m_I, 6a57_A, 2wbs_A, 5yj3_D, 4m9v_C |
| Binding Motifs: | MA0751.1 krCCCCCyGykGyGh MA0751.2 krCCCCCyGykGyG |
| Publications: | Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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