Transcription Factor
| Accessions: | T144583_1.02 (CISBP 1.02), Q8R316 (JASPAR 2024) |
| Names: | Hbp1, T144583_1.02;, HBP1_MOUSE, High mobility group box transcription factor 1, HMG box transcription factor 1, HMG box-containing protein 1 |
| Organisms: | Mus musculus |
| Libraries: | CISBP 1.02 1, JASPAR 2024 2 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | experiment type:PBM, family:Sox |
| Length: | 516 |
| Pfam Domains: | 215-339 Ataxin-1 and HBP1 module (AXH) 433-498 Domain of unknown function (DUF1898) 437-501 HMG (high mobility group) box |
| Sequence: (in bold interface residues) | 1 MVWEVKTNQMPNAVQKLLLVMDKRAPGMSDSLELLQCNENLPSSPGYNSCDEHMELDDLP 60 61 ELQAVQSDPTQSAIYQLSSDVSHQEYPRSSWSQNTSDIPENTHREDEVDWLTELANIATS 120 121 PQSPLMQCSFYNRSSPVHIIATSKSLHSYARPPPVSSSSKSGPAFPHDHWKEETPVRHER 180 181 ANSESESGIFCMSSLSDDDDLGWCNSWPSTIWHCFLKGTRLCFHKESNKEWQDVEDFARA 240 241 ASCDNEEEIQMGTHKGYGSDGLKLLSHEESVSFGESVLKLTFDPGTVEDGLLTVECKLDH 300 301 PFYVKNKGWSSFYPSLTVVQHGIPCCEIHIGDVCLPPGHPDAINFDDSGVFDTFKSYDFT 360 361 PMDSSAVYVLSSMARQRRASLSCGGGPGTGQEFSGSEFSKSCGSPGSSQLSSSSLYAKAV 420 421 KSHSSGTVSATSPNKCKRPMNAFMLFAKKYRVEYTQMYPGKDNRAISVILGDRWKKMKNE 480 481 ERRMYTLEAKALAEEQKRLNPDCWKRKRTNSGSQQH |
| Interface Residues: | 438, 441, 443, 444, 447, 451, 462, 463, 464, 467, 505, 507 |
| 3D-footprint Homologues: | 7m5w_A, 2gzk_A, 4s2q_D, 1j5n_A, 2lef_A, 4y60_C, 1o4x_B, 3f27_D, 6jrp_D, 1qrv_A, 3u2b_C, 1hry_A |
| Binding Motifs: | PB0028.1 wcwwTsAATGAATgry PB0132.1 wdkyCCCATTGTvhasw M1580_1.02 ycattswv |
| Publications: | Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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