Transcription Factor

						

			
Accessions: FLI1 (SMILE-seq 1.0)

			
Names: FLI1, FLI1_HUMAN, Friend leukemia integration 1 transcription factor, Proto-oncogene Fli-1, Transcription factor ERGB
Organisms: Homo sapiens
Libraries: SMILE-seq 1.0 1
1 Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed]
Uniprot: Q01543
Notes: TF family: ETS
Length: 451
Pfam Domains:   114-197 Sterile alpha motif (SAM)/Pointed domain
  280-362 Ets-domain
Sequence: 
(in bold interface residues)		   1 MDGTIKEALSVVSDDQSLFDSAYGAAAHLPKADMTASGSPDYGQPHKINPLPPQQEWINQ   60
  61 PVRVNVKREYDHMNGSRESPVDCSVSKCSKLVGGGESNPMNYNSYMDEKNGPPPPNMTTN  120
 121 ERRVIVPADPTLWTQEHVRQWLEWAIKEYSLMEIDTSFFQNMDGKELCKMNKEDFLRATT  180
 181 LYNTEVLLSHLSYLRESSLLAYNTTSHTDQSSRLSVKEDPSYDSVRRGAWGNNMNSGLNK  240
 241 SPPLGGAQTISKNTEQRPQPDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSANASCI  300
 301 TWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKF  360
 361 DFHGIAQALQPHPTESSMYKYPSDISYMPSYHAHQQKVNFVPPHPSSMPVTSSSFFGAAS  420
 421 QYWTSPTGGIYPNPNVPRHPNTHVPSHLGSY
Interface Residues: 278, 333, 334, 336, 337, 338, 340, 341, 355
3D-footprint Homologues: 3zp5_A, 1dux_F, 7jsa_J, 8ee9_F, 4mhg_A, 2stt_A, 4uno_A, 3jtg_A, 4l18_B, 4lg0_B, 1yo5_C, 4bqa_A, 1awc_A, 4iri_A, 1bc8_C
Binding Motifs: FLI1 yayTTCCGGt
			
Publications: Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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