Transcription Factor
| Accessions: | ESR2_HUMAN (HOCOMOCO 10), Q92731 (JASPAR 2024) |
| Names: | ER-beta, ESR2_HUMAN, Estrogen receptor beta, Nuclear receptor subfamily 3 group A member 2 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 530 |
| Pfam Domains: | 12-123 Estrogen receptor beta 148-216 Zinc finger, C4 type (two domains) 282-475 Ligand-binding domain of nuclear hormone receptor |
| Sequence: (in bold interface residues) | 1 MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPS 60 61 NVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVN 120 121 RETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGH 180 181 NDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLH 240 241 CAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTK 300 301 LADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDL 360 361 VLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDA 420 421 DSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMK 480 481 CKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ |
| Interface Residues: | 157, 158, 160, 161, 167, 168, 170, 171, 174, 175, 199, 221, 223, 247, 251 |
| 3D-footprint Homologues: | 6fbq_A, 6l6q_B, 7wnh_D, 1lo1_A, 3g9m_B, 1a6y_A, 4oln_B, 1dsz_A, 4umm_E, 3cbb_A, 8cef_H, 4iqr_B, 2han_A, 1hcq_E, 8hbm_B, 5krb_G, 2han_B, 1kb2_B, 2a66_A, 2nll_B, 1lat_A, 7xv6_B, 2ff0_A, 5emc_A, 7prw_B, 5cbx_B, 3g6t_A, 1r4i_A, 5cbz_E, 4tnt_B, 5e69_A, 4hn5_B |
| Binding Motifs: | MA0258.1 cwrGGTCAsgkTGmCCys MA0258.2 rGGTCAsmstGaCCy ESR2_HUMAN.H10MO.A|M01120 mrGGtCAgksTGaCCykg UN0308.1 sycAGGTCAgss UN0308.2 AGGTCAg |
| Binding Sites: | MA0258.1.1 MA0258.1.10 MA0258.1.11 MA0258.1.12 MA0258.1.13 MA0258.1.14 MA0258.1.15 MA0258.1.16 MA0258.1.17 MA0258.1.18 MA0258.1.19 MA0258.1.2 MA0258.1.20 MA0258.1.3 MA0258.1.4 MA0258.1.5 MA0258.1.6 MA0258.1.7 MA0258.1.8 MA0258.1.9 MA0258.2.1 MA0258.2.10 MA0258.2.11 MA0258.2.12 MA0258.2.13 MA0258.2.14 MA0258.2.15 MA0258.2.16 MA0258.2.17 MA0258.2.18 MA0258.2.19 MA0258.2.2 MA0258.2.20 MA0258.2.3 MA0258.2.4 MA0258.2.5 MA0258.2.6 MA0258.2.7 MA0258.2.8 MA0258.2.9 UN0308.1.1 UN0308.1.10 / UN0308.1.9 UN0308.1.10 / UN0308.1.11 UN0308.1.12 UN0308.1.13 UN0308.1.11 / UN0308.1.14 UN0308.1.12 / UN0308.1.15 UN0308.1.13 / UN0308.1.16 UN0308.1.14 / UN0308.1.17 UN0308.1.18 UN0308.1.19 UN0308.1.2 UN0308.1.15 / UN0308.1.20 UN0308.1.3 UN0308.1.3 / UN0308.1.4 UN0308.1.5 UN0308.1.5 / UN0308.1.6 UN0308.1.6 / UN0308.1.7 UN0308.1.7 / UN0308.1.8 UN0308.1.8 / UN0308.1.9 UN0308.1.16 UN0308.1.17 UN0308.1.18 UN0308.1.19 UN0308.1.20 UN0308.1.4 UN0308.2.1 / UN0308.2.12 / UN0308.2.18 UN0308.2.10 UN0308.2.11 / UN0308.2.3 UN0308.2.13 / UN0308.2.17 / UN0308.2.5 / UN0308.2.7 UN0308.2.14 / UN0308.2.15 / UN0308.2.2 / UN0308.2.20 / UN0308.2.6 / UN0308.2.8 UN0308.2.16 / UN0308.2.9 UN0308.2.19 UN0308.2.4 |
| Publications: | Liu Y, Gao H, Marstrand T.T, Ström A, Valen E, Sandelin A, Gustafsson J.A, Dahlman-Wright K. The genome landscape of ERalpha- and ERbeta-binding DNA regions. Proceedings of the National Academy of Sciences of the United States of America 105:2604-9 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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