Transcription Factor

Accessions: ARNTL (SMILE-seq 1.0)
Names: ARNTL, B2RCL8_HUMAN
Organisms: Homo sapiens
Libraries: SMILE-seq 1.0 1
1 Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed]
Uniprot: B2RCL8
Notes: TF family: bHLH
Length: 624
Pfam Domains: 74-125 Helix-loop-helix DNA-binding domain
149-252 PAS fold
346-434 PAS fold
350-435 PAS fold
Sequence:
(in bold interface residues)
1 MADQRMDISSTISDFMSPGPTDLLSSSLGTSGVDCNRKRKGSSTDYQESMDTDKDDPHGR 60
61 LEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQ 120
121 HMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKIL 180
181 NYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLC 240
241 SGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDED 300
301 NEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAIL 360
361 AYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWF 420
421 SFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTASPHSMDSMLPSGEGGPKRTHPTV 480
481 PGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPLNITSTPPPDASSPGGKKIL 540
541 NGGTPDIPSSGLLSGQAQENPGYPYSDSSSILGENPHIGIDMIDNDQGSSSPSNDEAAMA 600
601 VIMSLLEADAGLGGPVDFSDLPWP
Interface Residues: 74, 76, 77, 78, 80, 81, 84, 85, 89, 109, 111
3D-footprint Homologues: 1a0a_B, 1an4_A, 7xi3_A, 5v0l_A, 7f2f_B, 4h10_A, 7ssa_L, 5nj8_D, 4h10_B, 7xq5_A, 6g1l_A, 5eyo_A, 1am9_A, 4zpk_A, 8osl_O, 7d8t_A, 5gnj_I, 8osl_P, 5nj8_C, 4zpk_B, 4zpr_B, 7xhv_B, 5sy7_B, 7xi3_B, 5v0l_B
Binding Motifs: ARNTL_CLOCK drtCACGTGm
Publications: Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.