Transcription Factor

Accessions: STAT3_HUMAN (HOCOMOCO 10), P40763 (JASPAR 2024)
Names: Acute-phase response factor, Signal transducer and activator of transcription 3, STAT3_HUMAN
Organisms: Homo sapiens
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: P40763
Length: 770
Pfam Domains: 2-121 STAT protein, protein interaction domain
139-319 STAT protein, all-alpha domain
321-574 STAT protein, DNA binding domain
584-674 SH2 domain
Sequence:
(in bold interface residues)
1 MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL 60
61 LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA 120
121 TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK 180
181 SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL 240
241 ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ 300
301 HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY 360
361 QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN 420
421 GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY 480
481 NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS 540
541 GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST 600
601 KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM 660
661 DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSN 720
721 TIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM
Interface Residues: 340, 427, 465, 466, 467, 468, 469, 685, 739, 742
3D-footprint Homologues: 1bf5_A, 1bg1_A, 4y5w_B, 6en1_A
Binding Motifs: MA0144.2 yTKCykGGAAr
STAT3_HUMAN.H10MO.A|M01542 yTTCCyrGMAr
MA0144.3 TKCykGGAA
Binding Sites: MA0144.2.1
MA0144.2.10
MA0144.2.11
MA0144.2.12
MA0144.2.13
MA0144.2.14
MA0144.2.15
MA0144.2.16
MA0144.2.17
MA0144.2.18
MA0144.2.19
MA0144.2.2
MA0144.2.20
MA0144.2.3
MA0144.2.4
MA0144.2.5
MA0144.2.6
MA0144.2.7
MA0144.2.8
MA0144.2.9
MA0144.3.6
MA0144.3.1
MA0144.3.10
MA0144.3.11
MA0144.3.12
MA0144.3.13
MA0144.3.14
MA0144.3.15
MA0144.3.16
MA0144.3.17
MA0144.3.18
MA0144.3.19
MA0144.3.2
MA0144.3.20
MA0144.3.3
MA0144.3.4
MA0144.3.5
MA0144.3.7
MA0144.3.8
MA0144.3.9
Publications: Chen X, Xu H, Yuan P, Fang F, Huss M, Vega V.B, Wong E, Orlov Y.L, Zhang W, Jiang J, Loh Y.H, Yeo H.C, Yeo Z.X, Narang V, Govindarajan K.R, Leong B, Shahab A, Ruan Y, Bourque G, Sung W.K, Clarke N.D, Wei C.L, Ng H.H. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 133:1106-17 (2008). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.