Transcription Factor
Accessions: | STAT3_HUMAN (HOCOMOCO 10), P40763 (JASPAR 2024) |
Names: | Acute-phase response factor, Signal transducer and activator of transcription 3, STAT3_HUMAN |
Organisms: | Homo sapiens |
Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
Uniprot: | P40763 |
Length: | 770 |
Pfam Domains: | 2-121 STAT protein, protein interaction domain 139-319 STAT protein, all-alpha domain 321-574 STAT protein, DNA binding domain 584-674 SH2 domain |
Sequence: (in bold interface residues) | 1 MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL 60 61 LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA 120 121 TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK 180 181 SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL 240 241 ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ 300 301 HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY 360 361 QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN 420 421 GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY 480 481 NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS 540 541 GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST 600 601 KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM 660 661 DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSN 720 721 TIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM |
Interface Residues: | 340, 427, 465, 466, 467, 468, 469, 685, 739, 742 |
3D-footprint Homologues: | 1bf5_A, 1bg1_A, 4y5w_B, 6en1_A |
Binding Motifs: | MA0144.2 yTKCykGGAAr STAT3_HUMAN.H10MO.A|M01542 yTTCCyrGMAr MA0144.3 TKCykGGAA |
Binding Sites: | MA0144.2.1 MA0144.2.10 MA0144.2.11 MA0144.2.12 MA0144.2.13 MA0144.2.14 MA0144.2.15 MA0144.2.16 MA0144.2.17 MA0144.2.18 MA0144.2.19 MA0144.2.2 MA0144.2.20 MA0144.2.3 MA0144.2.4 MA0144.2.5 MA0144.2.6 MA0144.2.7 MA0144.2.8 MA0144.2.9 MA0144.3.6 MA0144.3.1 MA0144.3.10 MA0144.3.11 MA0144.3.12 MA0144.3.13 MA0144.3.14 MA0144.3.15 MA0144.3.16 MA0144.3.17 MA0144.3.18 MA0144.3.19 MA0144.3.2 MA0144.3.20 MA0144.3.3 MA0144.3.4 MA0144.3.5 MA0144.3.7 MA0144.3.8 MA0144.3.9 |
Publications: | Chen X, Xu H, Yuan P, Fang F, Huss M, Vega V.B, Wong E, Orlov Y.L, Zhang W, Jiang J, Loh Y.H, Yeo H.C, Yeo Z.X, Narang V, Govindarajan K.R, Leong B, Shahab A, Ruan Y, Bourque G, Sung W.K, Clarke N.D, Wei C.L, Ng H.H. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 133:1106-17 (2008). [Pubmed] |
Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.