Transcription Factor
| Accessions: | ZNF250 (humanC2H2ZF-ChIP Feb2015), P15622 (JASPAR 2024) |
| Names: | ENSG00000196150, P15622, ZNF250, Zinc finger protein 250, Zinc finger protein 647, ZN250_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | humanC2H2ZF-ChIP Feb2015 1, JASPAR 2024 2 1 Najafabadi HS, Mnaimneh S, Schmitges FW, Garton M, Lam KN, Yang A, Albu M, Weirauch MT, Radovani E, Kim PM, Greenblatt J, Frey BJ, Hughes TR. C2H2 zinc finger proteins greatly expand the human regulatory lexicon. Nat Biotechnol 33:555-62 (2015). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | TF family: C2H2;KRAB experiment: ChIP-seq/MEME/B1H-RC |
| Length: | 560 |
| Pfam Domains: | 22-62 KRAB box 199-221 Zinc finger, C2H2 type 200-221 C2H2-type zinc finger 213-237 Zinc-finger double domain 227-247 C2H2-type zinc finger 227-249 Zinc finger, C2H2 type 227-249 C2H2-type zinc finger 242-264 Zinc-finger double domain 254-265 C2H2-type zinc finger 255-277 Zinc finger, C2H2 type 255-274 C2H2-type zinc finger 270-294 Zinc-finger double domain 282-303 C2H2-type zinc finger 283-305 Zinc finger, C2H2 type 283-305 C2H2-type zinc finger 298-322 Zinc-finger double domain 311-333 C2H2-type zinc finger 311-333 C2H2-type zinc finger 311-333 Zinc finger, C2H2 type 326-349 Zinc-finger double domain 338-357 C2H2-type zinc finger 339-361 C2H2-type zinc finger 339-361 Zinc finger, C2H2 type 354-377 Zinc-finger double domain 366-385 C2H2-type zinc finger 367-389 Zinc finger, C2H2 type 367-389 C2H2-type zinc finger 384-406 Zinc-finger double domain 394-413 C2H2-type zinc finger 395-417 Zinc finger, C2H2 type 395-417 C2H2-type zinc finger 410-433 Zinc-finger double domain 423-445 C2H2-type zinc finger 423-445 Zinc finger, C2H2 type 423-445 C2H2-type zinc finger 438-461 Zinc-finger double domain 451-469 C2H2-type zinc finger 451-473 Zinc finger, C2H2 type 451-473 C2H2-type zinc finger 466-489 Zinc-finger double domain 479-501 C2H2-type zinc finger 479-501 Zinc finger, C2H2 type 479-501 C2H2-type zinc finger 496-517 Zinc-finger double domain 506-527 C2H2-type zinc finger 507-529 Zinc finger, C2H2 type 507-529 C2H2-type zinc finger 523-545 Zinc-finger double domain 534-559 C2H2-type zinc finger 535-557 C2H2-type zinc finger 535-557 Zinc finger, C2H2 type |
| Sequence: (in bold interface residues) | 1 MAAARLLPVPAGPQPLSFQAKLTFEDVAVLLSQDEWDRLCPAQRGLYRNVMMETYGNVVS 60 61 LGLPGSKPDIISQLERGEDPWVLDRKGAKKSQGLWSDYSDNLKYDHTTACTQQDSLSCPW 120 121 ECETKGESQNTDLSPKPLISEQTVILGKTPLGRIDQENNETKQSFCLSPNSVDHREVQVL 180 181 SQSMPLTPHQAVPSGERPYMCVECGKCFGRSSHLLQHQRIHTGEKPYVCSVCGKAFSQSS 240 241 VLSKHRRIHTGEKPYECNECGKAFRVSSDLAQHHKIHTGEKPHECLECRKAFTQLSHLIQ 300 301 HQRIHTGERPYVCPLCGKAFNHSTVLRSHQRVHTGEKPHRCNECGKTFSVKRTLLQHQRI 360 361 HTGEKPYTCSECGKAFSDRSVLIQHHNVHTGEKPYECSECGKTFSHRSTLMNHERIHTEE 420 421 KPYACYECGKAFVQHSHLIQHQRVHTGEKPYVCGECGHAFSARRSLIQHERIHTGEKPFQ 480 481 CTECGKAFSLKATLIVHLRTHTGEKPYECNSCGKAFSQYSVLIQHQRIHTGEKPYECGEC 540 541 GRAFNQHGHLIQHQKVHRKL |
| Interface Residues: | 209, 210, 212, 213, 216, 220, 227, 237, 238, 239, 240, 241, 244, 245, 265, 266, 267, 268, 269, 270, 271, 272, 273, 276, 293, 294, 295, 296, 297, 299, 300, 303, 321, 322, 323, 324, 325, 327, 328, 350, 352, 353, 356, 377, 378, 379, 380, 381, 384, 405, 406, 407, 408, 409, 412, 418, 432, 433, 434, 435, 436, 437, 439, 440, 442, 443, 444, 446, 461, 462, 463, 464, 465, 468, 489, 490, 491, 492, 493, 495, 496, 518, 519, 520, 521, 522, 523, 524, 545, 546, 547, 548, 549 |
| 3D-footprint Homologues: | 6jnm_A, 6u9q_A, 1mey_C, 5kl3_A, 1f2i_J, 8ssq_A, 7w1m_H, 8ssu_A, 4x9j_A, 1llm_D, 7y3m_I, 2kmk_A, 5und_A, 1tf6_A, 4m9v_C, 7ysf_A, 7n5w_A, 5yj3_D, 2drp_D, 6wmi_A, 2lt7_A, 5v3j_F, 1tf3_A, 7eyi_G, 6e94_A, 2i13_A, 8gn3_A, 6ml4_A, 5yel_A, 5ei9_F, 7txc_E, 6blw_A, 5kkq_D, 6a57_A, 2jpa_A, 1ubd_C, 8cuc_F, 7y3l_A, 5k5i_A, 2gli_A, 1g2f_F, 3uk3_C, 5k5l_F, 8h9h_G, 2wbs_A |
| Binding Motifs: | ZNF250_ChIP AAAAkTGCAmsr UN0604.1 taATCAAAACAGtr |
| Binding Sites: | UN0604.1.1 UN0604.1.10 / UN0604.1.8 UN0604.1.11 / UN0604.1.9 UN0604.1.10 / UN0604.1.12 UN0604.1.11 / UN0604.1.13 UN0604.1.12 / UN0604.1.14 UN0604.1.13 / UN0604.1.15 UN0604.1.14 / UN0604.1.16 UN0604.1.17 UN0604.1.16 / UN0604.1.18 UN0604.1.17 / UN0604.1.19 UN0604.1.2 UN0604.1.19 / UN0604.1.20 UN0604.1.3 UN0604.1.4 UN0604.1.4 / UN0604.1.5 UN0604.1.5 / UN0604.1.6 UN0604.1.6 / UN0604.1.7 UN0604.1.8 UN0604.1.7 / UN0604.1.9 UN0604.1.15 UN0604.1.18 UN0604.1.20 |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.