Transcription Factor

Accessions: P40427 (JASPAR 2024)
Names: Dpbx, EXD_DROME, Homeobox protein extradenticle
Organisms: Drosophila melanogaster
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 376
Pfam Domains: 37-237 PBC domain
239-298 Homeobox domain
257-295 Homeobox KN domain
Sequence:
(in bold interface residues)
1 MEDPNRMLAHTGGMMAPQGYGLSGQDDGQNAGSENEVRKQKDIGEILQQIMSISEQSLDE 60
61 AQARKHTLNCHRMKPALFSVLCEIKEKTVLSIRNTQEEEPPDPQLMRLDNMLIAEGVAGP 120
121 EKGGGGAAAASAAAASQGGSLSIDGADNAIEHSDYRAKLAQIRQIYHQELEKYEQACNEF 180
181 TTHVMNLLREQSRTRPITPKEIERMVQIIHKKFSSIQMQLKQSTCEAVMILRSRFLDARR 240
241 KRRNFSKQASEILNEYFYSHLSNPYPSEEAKEELARKCGITVSQVSNWFGNKRIRYKKNI 300
301 GKAQEEANLYAAKKAAGASPYSMAGPPSGTTTPMMSPAPPQDSMGYPMGSGGYDQQQPYD 360
361 NSMGGYDPNLHQDLSP
Interface Residues: 212, 218, 221, 222, 225, 239, 240, 241, 242, 243, 283, 284, 286, 287, 290, 291, 294, 295, 298
3D-footprint Homologues: 1au7_A, 5zfz_A, 2h1k_B, 1fjl_B, 6a8r_A, 3d1n_M, 6fqp_B, 1puf_A, 3cmy_A, 2lkx_A, 1zq3_P, 1jgg_B, 3lnq_A, 2ld5_A, 5hod_A, 1puf_B, 5jlw_D, 4cyc_A, 2r5y_A, 3l1p_A, 7psx_B, 1b72_A, 4j19_B, 3a01_E, 5zjt_E, 3rkq_B, 1le8_A, 7q3o_C, 6fqq_E, 4xrm_B, 2hdd_A, 1le8_B, 6m3d_C, 6es3_K, 4xrs_G, 1mnm_C, 2d5v_B, 1k61_B, 5flv_I, 1du0_A, 4qtr_D, 2hos_A
Binding Motifs: MA0222.1 tTTTGAYr
MA0222.2 TTTGAYr
Binding Sites: MA0222.2.16 / MA0222.2.6
MA0222.2.15 / MA0222.2.7
MA0222.1.1
MA0222.1.10
MA0222.1.11
MA0222.1.12
MA0222.1.13
MA0222.1.14
MA0222.1.15 / MA0222.1.7
MA0222.1.16
MA0222.1.17
MA0222.1.18
MA0222.1.19
MA0222.1.2
MA0222.1.20
MA0222.1.3
MA0222.1.4
MA0222.1.5
MA0222.1.6
MA0222.1.8
MA0222.1.9
MA0222.2.1
MA0222.2.10
MA0222.2.11
MA0222.2.12 / MA0222.2.5
MA0222.2.13
MA0222.2.14
MA0222.2.17
MA0222.2.18
MA0222.2.19
MA0222.2.2
MA0222.2.20
MA0222.2.3
MA0222.2.4
MA0222.2.8
MA0222.2.9
Publications: Noyes M.B, Christensen R.G, Wakabayashi A, Stormo G.D, Brodsky M.H, Wolfe S.A. Analysis of homeodomain specificities allows the family-wide prediction of preferred recognition sites. Cell 133:1277-89 (2008). [Pubmed]
Related annotations: PaperBLAST

Disclaimer and license

These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.