Transcription Factor

						

			
Accessions: CLOCK (SMILE-seq 1.0)

			
Names: Circadian clock protein PERIOD 1, Circadian pacemaker protein Rigui, CLOCK, hPER1, PER1_HUMAN, Period circadian protein homolog 1
Organisms: Homo sapiens
Libraries: SMILE-seq 1.0 1
1 Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed]
Uniprot: O15534
Notes: TF family: bHLH
Length: 845
Pfam Domains:     35-83 Helix-loop-helix DNA-binding domain
  110-176 PAS fold
  287-373 PAS fold
Sequence: 
(in bold interface residues)		   1 MLFTVSCSKMSSIVDRDDSSIFDGLVEEDDKDKAKRVSRNKSEKKRRDQFNVLIKELGSM   60
  61 LPGNARKMDKSTVLQKSIDFLRKHKEITAQSDASEIRQDWKPTFISNEEFTQLMLEALDG  120
 121 FFLAIMTDGSIIYVSESVTSLLEHLPSDLVDQSIFNFIPEGEHSEVYKILSTHLLESDSL  180
 181 TPEYLKSKNQLEFCCHMLRGTIDPKEPSTYEYVKFIGNFKSLNSVSSSAHNGFEGTIQRT  240
 241 HRPSYEDRVCFVATVRLATPQFIKEMCTVEEPNEEFTSRHSLEWKFLFLDHRAPPIIGYL  300
 301 PFEVLGTSGYDYYHVDDLENLAKCHEHLMQYGKGKSCYYRFLTKGQQWIWLQTHYYITYH  360
 361 QWNSRPEFIVCTHTVVSYAEVRAERRRELGIEESLPETAADKSQDSGSDNRINTVSLKEA  420
 421 LERFDHSPTPSASSRSSRKSSHTAVSDPSSTPTKIPTDTSTPPRQHLPAHEKMVQRRSSF  480
 481 SSQSINSQSVGSSLTQPVMSQATNLPIPQGMSQFQFSAQLGAMQHLKDQLEQRTRMIEAN  540
 541 IHRQQEELRKIQEQLQMVHGQGLQMFLQQSNPGLNFGSVQLSSGNSSNIQQLAPINMQGQ  600
 601 VVPTNQIQSGMNTGHIGTTQHMIQQQTLQSTSTQSQQNVLSGHSQQTSLPSQTQSTLTAP  660
 661 LYNTMVISQPAAGSMVQIPSSMPQNSTQSAAVTTFTQDRQIRFSQGQQLVTKLVTAPVAC  720
 721 GAVMVPSTMLMGQVVTAYPTFATQQQQSQTLSVTQQQQQQSSQEQQLTSVQQPSQAQLTQ  780
 781 PPQQFLQTSRLLHGNPSTQLILSAAFPLQQSTFPQSHHQQHQSQQQQQLSRHRTDSLPDP  840
 841 SKVQP
Interface Residues: 34, 36, 38, 39, 40, 42, 43, 45, 46, 47, 70, 426
3D-footprint Homologues: 5sy7_B, 1a0a_B, 4zpk_B, 5nj8_D, 1am9_A, 7xi3_B, 6g1l_A, 4zpk_A, 7ssa_L, 8osl_O, 7xhv_B, 5v0l_A, 4h10_A, 7d8t_A, 7xi3_A, 4h10_B, 7f2f_B, 2ypa_B, 8osl_P, 5nj8_C, 5v0l_B, 7cli_B, 1a3q_A
Binding Motifs: ARNTL_CLOCK drtCACGTGm
			
Publications: Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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