Transcription Factor
| Accessions: | T025281_1.02 (CISBP 1.02), NFE2_HUMAN (HOCOMOCO 10), Q16621 (JASPAR 2024) |
| Names: | NFE2, T025281_1.02;, Leucine zipper protein NF-E2, NFE2_HUMAN, Nuclear factor, erythroid-derived 2 45 kDa subunit, p45 NF-E2, Transcription factor NF-E2 45 kDa subunit |
| Organisms: | Homo sapiens |
| Libraries: | CISBP 1.02 1, HOCOMOCO 10 2, JASPAR 2024 3 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | family:bZIP |
| Length: | 373 |
| Pfam Domains: | 239-329 bZIP Maf transcription factor 269-310 bZIP transcription factor |
| Sequence: (in bold interface residues) | 1 MSPCPPQQSRNRVIQLSTSELGEMELTWQEIMSITELQGLNAPSEPSFEPQAPAPYLGPP 60 61 PPTTYCPCSIHPDSGFPLPPPPYELPASTSHVPDPPYSYGNMAIPVSKPLSLSGLLSEPL 120 121 QDPLALLDIGLPAGPPKPQEDPESDSGLSLNYSDAESLELEGTEAGRRRSEYVEMYPVEY 180 181 PYSLMPNSLAHSNYTLPAAETPLALEPSSGPVRAKPTARGEAGSRDERRALAMKIPFPTD 240 241 KIVNLPVDDFNELLARYPLTESQLALVRDIRRRGKNKVAAQNCRKRKLETIVQLERELER 300 301 LTNERERLLRARGEADRTLEVMRQQLTELYRDIFQHLRDESGNSYSPEEYALQQAADGTI 360 361 FLVPRGTKMEATD |
| Interface Residues: | 272, 276, 277, 279, 280, 283, 284, 287 |
| 3D-footprint Homologues: | 2wt7_B, 1skn_P, 4eot_A, 7x5e_E, 7x5e_F, 2wt7_A, 5vpe_C, 5vpe_D, 2dgc_A, 5t01_B |
| Binding Motifs: | MA0841.1 vATGACTCATs MA0501.1 rTGACTCAGCArwwy M3617_1.02 rTGAsTCAGCa NFE2_HUMAN.H10MO.B|M01361 rsvrTGACTCAGCA MA0501.2 rTGACTCAGCA MA0841.2 ATGACTCATs |
| Binding Sites: | MA0501.1.1 MA0501.1.10 MA0501.1.11 MA0501.1.12 / MA0501.1.9 MA0501.1.13 MA0501.1.14 MA0501.1.15 MA0501.1.16 MA0501.1.17 MA0501.1.18 MA0501.1.19 MA0501.1.2 MA0501.1.20 MA0501.1.3 MA0501.1.4 MA0501.1.5 MA0501.1.6 MA0501.1.7 MA0501.1.8 MA0501.2.1 MA0501.2.10 MA0501.2.11 MA0501.2.12 MA0501.2.13 / MA0501.2.6 MA0501.2.14 MA0501.2.15 MA0501.2.16 MA0501.2.17 MA0501.2.18 MA0501.2.19 MA0501.2.2 MA0501.2.20 MA0501.2.3 MA0501.2.4 MA0501.2.5 MA0501.2.7 MA0501.2.8 MA0501.2.9 |
| Publications: | Blank V., Kim M. J., Andrews N. C. Human MafG is a functional partner for p45 NF-E2 in activating globin gene expression. Blood 89:3925-3935 (1997). [Pubmed] Daftari P, Gavva NR, Shen CK. Distinction between AP1 and NF-E2 factor-binding at specific chromatin regions in mammalian cells. Oncogene 18:5482-6 (1999). [Pubmed] |
| Related annotations: | PaperBLAST |
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