Transcription Factor

Accessions: JUN (SMILE-seq 1.0)
Names: Activator protein 1, AP1, JUN, JUN_HUMAN, p39, Proto-oncogene c-Jun, Transcription factor AP-1, V-jun avian sarcoma virus 17 oncogene homolog
Organisms: Homo sapiens
Libraries: SMILE-seq 1.0 1
1 Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed]
Uniprot: P05412
Notes: TF family: bZIP
Length: 330
Pfam Domains: 5-241 Jun-like transcription factor
250-313 bZIP transcription factor
255-310 Basic region leucine zipper
Sequence:
(in bold interface residues)
1 MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDL 60
61 LTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120
121 LHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGA 180
181 LSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETP 240
241 PLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANM 300
301 LREQVAQLKQKVMNHVNSGCQLMLTQQLQT
Interface Residues: 258, 259, 261, 262, 263, 265, 266, 269, 270, 273
3D-footprint Homologues: 2wt7_B, 1skn_P, 4eot_A, 7x5e_F, 1gd2_G, 2wt7_A, 1nwq_C, 5vpe_D, 1dh3_C, 2dgc_A, 5t01_B, 5vpe_C
Binding Motifs: JUN_1 kATGmGTCATc
JUN_2 atrkATGACGTMAtmsk
JUN_FOSB_1 krTGACTCAy
JUN_FOSB_2 gaTGACGTCAy
JUN_FOSL1_1 kkrTGACTCAtmm
JUN_FOSL1_2 rTgACGTcAy
JUN_FOSL2_1 kkrTGAGTCAym
JUN_FOSL2_2 grTGACGTmAt
JUN_FOS_1 rTGAGTCAym
JUN_FOS_2 drTgACGTCAtmmkty
JUN_JUNB_1 kaTGACkCAt
JUN_JUNB_2 krTGACGTCATb
Publications: Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed]
Related annotations: PaperBLAST

Disclaimer and license

These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.