Transcription Factor
Accessions: | JUN (SMILE-seq 1.0) |
Names: | Activator protein 1, AP1, JUN, JUN_HUMAN, p39, Proto-oncogene c-Jun, Transcription factor AP-1, V-jun avian sarcoma virus 17 oncogene homolog |
Organisms: | Homo sapiens |
Libraries: | SMILE-seq 1.0 1 1 Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed] |
Uniprot: | P05412 |
Notes: | TF family: bZIP |
Length: | 330 |
Pfam Domains: | 5-241 Jun-like transcription factor 250-313 bZIP transcription factor 255-310 Basic region leucine zipper |
Sequence: (in bold interface residues) | 1 MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDL 60 61 LTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120 121 LHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGA 180 181 LSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETP 240 241 PLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANM 300 301 LREQVAQLKQKVMNHVNSGCQLMLTQQLQT |
Interface Residues: | 258, 259, 261, 262, 263, 265, 266, 269, 270, 273 |
3D-footprint Homologues: | 2wt7_B, 1skn_P, 4eot_A, 7x5e_F, 1gd2_G, 2wt7_A, 1nwq_C, 5vpe_D, 1dh3_C, 2dgc_A, 5t01_B, 5vpe_C |
Binding Motifs: | JUN_1 kATGmGTCATc JUN_2 atrkATGACGTMAtmsk JUN_FOSB_1 krTGACTCAy JUN_FOSB_2 gaTGACGTCAy JUN_FOSL1_1 kkrTGACTCAtmm JUN_FOSL1_2 rTgACGTcAy JUN_FOSL2_1 kkrTGAGTCAym JUN_FOSL2_2 grTGACGTmAt JUN_FOS_1 rTGAGTCAym JUN_FOS_2 drTgACGTCAtmmkty JUN_JUNB_1 kaTGACkCAt JUN_JUNB_2 krTGACGTCATb |
Publications: | Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed] |
Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.