Transcription Factor

						

			
Accessions: ZNF454 (humanC2H2ZF-ChIP Feb2015), Q8N9F8 (JASPAR 2024)

			
Names: ENSG00000178187, Q8N9F8, ZNF454, ZN454_HUMAN
Organisms: Homo sapiens
Libraries: humanC2H2ZF-ChIP Feb2015 1, JASPAR 2024 2
1 Najafabadi HS, Mnaimneh S, Schmitges FW, Garton M, Lam KN, Yang A, Albu M, Weirauch MT, Radovani E, Kim PM, Greenblatt J, Frey BJ, Hughes TR. C2H2 zinc finger proteins greatly expand the human regulatory lexicon. Nat Biotechnol 33:555-62 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: TF family: C2H2;KRAB experiment: ChIP-seq/MEME/B1H-RC
Length: 522
Pfam Domains:     14-54 KRAB box
  178-200 Zinc finger, C2H2 type
  178-198 C2H2-type zinc finger
  178-200 C2H2-type zinc finger
  193-226 Zinc-finger double domain
  216-238 C2H2-type zinc finger
  216-238 Zinc finger, C2H2 type
  216-232 C2H2-type zinc finger
  234-254 Zinc-finger double domain
  243-264 C2H2-type zinc finger
  244-266 C2H2-type zinc finger
  244-266 Zinc finger, C2H2 type
  258-281 Zinc-finger double domain
  272-294 Zinc finger, C2H2 type
  287-311 Zinc-finger double domain
  300-322 C2H2-type zinc finger
  314-338 Zinc-finger double domain
  327-348 C2H2-type zinc finger
  328-350 C2H2-type zinc finger
  328-350 Zinc finger, C2H2 type
  343-365 Zinc-finger double domain
  356-378 C2H2-type zinc finger
  356-378 Zinc finger, C2H2 type
  356-376 C2H2-type zinc finger
  370-393 Zinc-finger double domain
  383-404 C2H2-type zinc finger
  384-406 C2H2-type zinc finger
  384-406 Zinc finger, C2H2 type
  399-421 Zinc-finger double domain
  412-432 C2H2-type zinc finger
  412-434 C2H2-type zinc finger
  412-434 Zinc finger, C2H2 type
  426-450 Zinc-finger double domain
  439-460 C2H2-type zinc finger
  440-462 Zinc finger, C2H2 type
  440-462 C2H2-type zinc finger
  454-477 Zinc-finger double domain
  467-486 C2H2-type zinc finger
  468-490 C2H2-type zinc finger
  468-490 Zinc finger, C2H2 type
  482-506 Zinc-finger double domain
  495-518 C2H2-type zinc finger
  496-518 C2H2-type zinc finger
  496-518 Zinc finger, C2H2 type
Sequence: 
(in bold interface residues)		   1 MAVSHLPTMVQESVTFKDVAILFTQEEWGQLSPAQRALYRDVMLENYSNLVSLGLLGPKP   60
  61 DTFSQLEKREVWMPEDTPGGFCLDWMTMPASKKSTVKAEIPEEELDQWTIKERFSSSSHW  120
 121 KCASLLEWQCGGQEISLQRVVLTHPNTPSQECDESGSTMSSSLHSDQSQGFQPSKNAFEC  180
 181 SECGKVFSKSSTLNKHQKIHNEKNANQKIHIKEKRYECRECGKAFHQSTHLIHHQRIHTG  240
 241 EKPYECKECGKAFSVSSSLTYHQKIHTGEKPFECNLCGKAFIRNIHLAHHHRIHTGEKPF  300
 301 KCNICEKAFVCRAHLTKHQNIHSGEKPYKCNECGKAFNQSTSFLQHQRIHTGEKPFECNE  360
 361 CGKAFRVNSSLTEHQRIHTGEKPYKCNECGKAFRDNSSFARHRKIHTGEKPYRCGLCEKA  420
 421 FRDQSALAQHQRIHTGEKPYTCNICEKAFSDHSALTQHKRIHTREKPYKCKICEKAFIRS  480
 481 THLTQHQRIHTGEKPYKCNKCGKAFNQTANLIQHQRHHIGEK
Interface Residues: 189, 191, 192, 226, 227, 229, 230, 232, 233, 235, 236, 239, 254, 255, 257, 258, 261, 265, 282, 283, 284, 285, 286, 288, 289, 292, 311, 312, 313, 314, 316, 317, 321, 338, 339, 340, 341, 342, 345, 356, 366, 367, 368, 369, 370, 372, 373, 374, 377, 394, 395, 396, 397, 398, 399, 400, 401, 402, 422, 423, 424, 425, 426, 428, 429, 451, 452, 453, 454, 456, 457, 463, 477, 478, 479, 480, 481, 482, 485, 489, 506, 507, 508, 509, 510, 512, 513
3D-footprint Homologues: 5k5l_F, 1tf3_A, 2i13_A, 2jpa_A, 8cuc_F, 7y3l_A, 8ssq_A, 7w1m_H, 8ssu_A, 1tf6_A, 8gn3_A, 2wbs_A, 5kl3_A, 7y3m_I, 5yj3_D, 5yel_A, 6wmi_A, 5v3j_F, 7eyi_G, 2lt7_A, 6jnm_A, 2gli_A, 1g2f_F, 5ei9_F, 1mey_C, 7txc_E, 2kmk_A, 3uk3_C, 5und_A, 5kkq_D, 4m9v_C, 7ysf_A, 6e94_A, 1ubd_C, 6ml4_A, 6u9q_A, 7n5w_A, 5k5i_A, 6blw_A, 2drp_D, 1f2i_J, 4x9j_A, 8h9h_G, 6a57_A, 1llm_D
Binding Motifs: UN0193.1 TrGCGCCGGCGCyw
UN0192.1 trGCGCCwGGCGCya
ZNF454_ChIP AArGCwC
MA1712.1 aGGCTCssGGcCCykvkG
MA1712.2 GGCTCssGGcCCykvkG
			
Publications: Schmitges FW, Radovani E, Najafabadi HS, Barazandeh M, Campitelli LF, Yin Y, Jolma A, Zhong G, Guo H, Kanagalingam T, Dai WF, Taipale J, Emili A, Greenblatt JF, Hughes TR. Multiparameter functional diversity of human C2H2 zinc finger proteins. Genome Res 26:1742-1752 (2016). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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