Transcription Factor

						

			
Accessions: ZN143_HUMAN (HOCOMOCO 10), P52747 (JASPAR 2024)

			
Names: hStaf, Selenocysteine tRNA gene transcription-activating factor, SPH-binding factor, Zinc finger protein 143, ZN143_HUMAN
Organisms: Homo sapiens
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: P52747
Length: 638
Pfam Domains:   237-261 Zinc finger, C2H2 type
  237-261 C2H2-type zinc finger
  253-280 Zinc-finger double domain
  267-291 Zinc finger, C2H2 type
  267-291 C2H2-type zinc finger
  284-310 Zinc-finger double domain
  297-321 Zinc finger, C2H2 type
  297-321 C2H2-type zinc finger
  313-340 Zinc-finger double domain
  327-351 C2H2-type zinc finger
  346-369 Zinc-finger double domain
  357-381 Zinc finger, C2H2 type
  357-381 C2H2-type zinc finger
  373-399 Zinc-finger double domain
  387-411 C2H2-type zinc finger
  417-440 C2H2-type zinc finger
  417-440 Zinc finger, C2H2 type
Sequence: 
(in bold interface residues)		   1 MLLAQINRDSQGMTEFPGGGMEAQHVTLCLTEAVTVADGDNLENMEGVSLQAVTLADGST   60
  61 AYIQHNSKDAKLIDGQVIQLEDGSAAYVQHVPIPKSTGDSLRLEDGQAVQLEDGTTAFIH  120
 121 HTSKDSYDQSALQAVQLEDGTTAYIHHAVQVPQSDTILAIQADGTVAGLHTGDATIDPDT  180
 181 ISALEQYAAKVSIDGSESVAGTGMIGENEQEKKMQIVLQGHATRVTAKSQQSGEKAFRCE  240
 241 YDGCGKLYTTAHHLKVHERSHTGDRPYQCEHAGCGKAFATGYGLKSHVRTHTGEKPYRCS  300
 301 EDNCTKSFKTSGDLQKHIRTHTGERPFKCPFEGCGRSFTTSNIRKVHVRTHTGERPYYCT  360
 361 EPGCGRAFASATNYKNHVRIHTGEKPYVCTVPGCDKRFTEYSSLYKHHVVHTHSKPYNCN  420
 421 HCGKTYKQISTLAMHKRTAHNDTEPIEEEQEAFFEPPPGQGEDVLKGSQITYVTGVEGDD  480
 481 VVSTQVATVTQSGLSQQVTLISQDGTQHVNISQADMQAIGNTITMVTQDGTPITVPAHDA  540
 541 VISSAGTHSVAMVTAEGTEGEQVAIVAQDLAAFHTASSEMGHQQHSHHLVTTETRPLTLV  600
 601 ATSNGTQIAVQLGEQPSLEEAIRIASRIQQGETPGLDD
Interface Residues: 218, 221, 224, 229, 249, 250, 252, 253, 256, 279, 280, 281, 282, 283, 285, 286, 309, 310, 311, 312, 313, 315, 316, 318, 319, 322, 337, 338, 339, 340, 341, 342, 343, 344, 345, 346, 347, 349, 350, 370, 371, 372, 373, 374, 375, 376, 377, 400, 401, 402, 403, 404, 405, 406, 407, 428, 429, 430, 431, 432, 434, 437
3D-footprint Homologues: 8ssu_A, 8ssq_A, 3uk3_C, 5v3j_F, 6u9q_A, 7w1m_H, 7ysf_A, 1tf3_A, 5k5i_A, 6ml4_A, 1g2f_F, 6blw_A, 1tf6_A, 2i13_A, 5ei9_F, 1mey_C, 5und_A, 1ubd_C, 8cuc_F, 7y3l_A, 7n5w_A, 6jnm_A, 1f2i_J, 2kmk_A, 2gli_A, 8gn3_A, 5kkq_D, 4x9j_A, 1llm_D, 2wbs_A, 6wmi_A, 7eyi_G, 8h9h_G, 7y3m_I, 6a57_A, 5yel_A, 2jpa_A, 7txc_E, 5kl3_A, 4m9v_C, 6e94_A, 2drp_D, 5yj3_D, 2lt7_A
Binding Motifs: MA0088.2 ywCCCAyAATGCAyyG
ZN143_HUMAN.H10MO.A|M01622 kcrwkGCAtkmTGGGArdtvyw
			
Publications: Schaub M., Myslinski E., Schuster C., Krol A., Carbon P. Staf, a promiscuous activator for enhanced transcription by RNA polymerases II and IIII. EMBO J. 16:173-181 (1997). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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