Transcription Factor

Accessions: ZNF35 (humanC2H2ZF-ChIP Feb2015)
Names: ENSG00000169981, P13682, ZNF35
Organisms: Homo sapiens
Libraries: humanC2H2ZF-ChIP Feb2015 1
1 Najafabadi HS, Mnaimneh S, Schmitges FW, Garton M, Lam KN, Yang A, Albu M, Weirauch MT, Radovani E, Kim PM, Greenblatt J, Frey BJ, Hughes TR. C2H2 zinc finger proteins greatly expand the human regulatory lexicon. Nat Biotechnol 33:555-62 (2015). [Pubmed]
Notes: TF family: C2H2 experiment: ChIP-seq/MEME/B1H-RC
Length: 527
Pfam Domains: 215-232 Zinc-finger double domain
221-242 C2H2-type zinc finger
222-244 C2H2-type zinc finger
222-244 Zinc finger, C2H2 type
236-259 Zinc-finger double domain
250-272 Zinc finger, C2H2 type
250-268 C2H2-type zinc finger
264-289 Zinc-finger double domain
278-300 C2H2-type zinc finger
278-300 Zinc finger, C2H2 type
278-298 C2H2-type zinc finger
292-317 Zinc-finger double domain
305-328 C2H2-type zinc finger
306-328 C2H2-type zinc finger
306-328 Zinc finger, C2H2 type
321-345 Zinc-finger double domain
334-356 C2H2-type zinc finger
334-356 Zinc finger, C2H2 type
334-354 C2H2-type zinc finger
348-373 Zinc-finger double domain
362-384 Zinc finger, C2H2 type
362-384 C2H2-type zinc finger
362-384 C2H2-type zinc finger
376-401 Zinc-finger double domain
389-410 C2H2-type zinc finger
390-412 Zinc finger, C2H2 type
390-412 C2H2-type zinc finger
405-428 Zinc-finger double domain
418-440 Zinc finger, C2H2 type
418-438 C2H2-type zinc finger
418-440 C2H2-type zinc finger
435-457 Zinc-finger double domain
446-468 C2H2-type zinc finger
446-468 Zinc finger, C2H2 type
446-460 C2H2-type zinc finger
461-484 Zinc-finger double domain
473-496 C2H2-type zinc finger
474-496 C2H2-type zinc finger
474-496 Zinc finger, C2H2 type
488-511 Zinc-finger double domain
502-524 C2H2-type zinc finger
502-524 Zinc finger, C2H2 type
Sequence:
(in bold interface residues)
1 MTAELREAMALAPWGPVKVKKEEEEEENFPGQASSQQVHSENIKVWAPVQGLQTGLDGSE 60
61 EEEKGQNISWDMAVVLKATQEAPAASTLGSYSLPGTLAKSEILETHGTMNFLGAETKNLQ 120
121 LLVPKTEICEEAEKPLIISERIQKADPQGPELGEACEKGNMLKRQRIKREKKDFRQVIVN 180
181 DCHLPESFKEEENQKCKKSGGKYSLNSGAVKNPKTQLGQKPFTCSVCGKGFSQSANLVVH 240
241 QRIHTGEKPFECHECGKAFIQSANLVVHQRIHTGQKPYVCSKCGKAFTQSSNLTVHQKIH 300
301 SLEKTFKCNECEKAFSYSSQLARHQKVHITEKCYECNECGKTFTRSSNLIVHQRIHTGEK 360
361 PFACNDCGKAFTQSANLIVHQRSHTGEKPYECKECGKAFSCFSHLIVHQRIHTAEKPYDC 420
421 SECGKAFSQLSCLIVHQRIHSGDLPYVCNECGKAFTCSSYLLIHQRIHNGEKPYTCNECG 480
481 KAFRQRSSLTVHQRTHTGEKPYECEKCGAAFISNSHLMRHHRTHLVE
Interface Residues: 211, 222, 232, 233, 234, 235, 236, 239, 243, 260, 261, 262, 263, 264, 266, 267, 288, 289, 290, 291, 292, 294, 295, 299, 316, 317, 318, 319, 320, 322, 323, 344, 345, 346, 347, 348, 350, 351, 353, 354, 357, 372, 373, 374, 375, 376, 379, 383, 400, 401, 402, 403, 404, 405, 407, 410, 428, 429, 430, 431, 432, 434, 435, 438, 441, 455, 456, 457, 458, 459, 460, 462, 463, 467, 484, 485, 486, 487, 488, 491, 492, 513, 514, 515, 516, 517, 519, 520
3D-footprint Homologues: 1ubd_C, 2kmk_A, 6jnm_A, 1llm_D, 5kkq_D, 1f2i_J, 5k5i_A, 8ssq_A, 7w1m_H, 5und_A, 1g2f_F, 8ssu_A, 4x9j_A, 6e94_A, 6a57_A, 6u9q_A, 7txc_E, 5yj3_D, 6ml4_A, 5yel_A, 7n5w_A, 8gn3_A, 2drp_D, 6wmi_A, 5v3j_F, 8h9h_G, 7eyi_G, 7ysf_A, 8cuc_F, 7y3l_A, 2i13_A, 6blw_A, 1mey_C, 2gli_A, 5k5l_F, 7y3m_I, 2jpa_A, 1tf3_A, 2wbs_A, 5kl3_A, 1tf6_A, 5ei9_F, 2lt7_A, 3uk3_C, 4m9v_C
Binding Motifs: ZNF35_ChIP ATATRTAAAGAG
Related annotations: PaperBLAST

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