Transcription Factor
| Accessions: | dsx (DrosophilaTF 1.1), P23023 (JASPAR 2024) |
| Names: | DSX_DROME |
| Organisms: | Drosophila melanogaster |
| Libraries: | DrosophilaTF 1.1 1, JASPAR 2024 2 1 Down T.A, Bergman C.M, Su J, Hubbard T.J. Large-scale discovery of promoter motifs in Drosophila melanogaster. PLoS computational biology 3:e7 (2007). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P23023 |
| Length: | 549 |
| Pfam Domains: | 41-86 DM DNA binding domain 351-410 Doublesex dimerisation domain |
| Sequence: (in bold interface residues) | 1 MVSEENWNSDTMSDSDMIDSKNDVCGGASSSSGSSISPRTPPNCARCRNHGLKITLKGHK 60 61 RYCKFRYCTCEKCRLTADRQRVMALQTALRRAQAQDEQRALHMHEVPPANPAATTLLSHH 120 121 HHVAAPAHVHAHHVHAHHAHGGHHSHHGHVLHHQQAAAAAAAAPSAPASHLGGSSTAASS 180 181 IHGHAHAHHVHMAAAAAASVAQHQHQSHPHSHHHHHQNHHQHPHQQPATQTALRSPPHSD 240 241 HGGSVGPATSSSGGGAPSSSNAAAATSSNGSSGGGGGGGGGSSGGGAGGGRSSGTSVITS 300 301 ADHHMTTVPTPAQSLEGSCDSSSPSPSSTSGAAILPISVSVNRKNGANVPLGQDVFLDYC 360 361 QKLLEKFRYPWELMPLMYVILKDADANIEEASRRIEEARVEINRTVAQIYYNYYTPMALV 420 421 NGAPMYLTYPSIEQGRYGAHFTHLPLTQICPPTPEPLALSRSPSSPSGPSAVHNQKPSRP 480 481 GSSNGTVHSAASPTMVTTMATTSSTPTLSRRQRSRSATPTTPPPPPPAHSSSNGAYHHGH 540 541 HLVSSTAAT |
| Interface Residues: | 39, 79, 83, 86, 87, 90, 91 |
| 3D-footprint Homologues: | 4yj0_C |
| Binding Motifs: | dsx byrmyACAATGTwdywy MA1836.1 hwACAATGTad MA1836.2 ACAATGT |
| Binding Sites: | dsx_1 dsx_10 dsx_15 dsx_16 dsx_19 dsx_25 dsx_26 dsx_27 dsx_28 dsx_30 dsx_31 dsx_32 dsx_35 dsx_37 dsx_39 dsx_40 dsx_42 dsx_43 dsx_44 dsx_45 dsx_47 dsx_49 dsx_5 dsx_50 dsx_51 dsx_54 dsx_55 dsx_57 dsx_58 dsx_59 dsx_6 dsx_61 dsx_9 MA1836.1.1 MA1836.1.10 MA1836.1.11 MA1836.1.12 / MA1836.1.13 MA1836.1.13 / MA1836.1.15 MA1836.1.14 / MA1836.1.16 MA1836.1.15 / MA1836.1.18 MA1836.1.16 / MA1836.1.19 MA1836.1.17 / MA1836.1.20 MA1836.1.18 MA1836.1.19 MA1836.1.1 / MA1836.1.2 MA1836.1.20 MA1836.1.2 / MA1836.1.3 MA1836.1.3 / MA1836.1.4 MA1836.1.5 MA1836.1.6 MA1836.1.7 MA1836.1.8 MA1836.1.9 MA1836.2.11 / MA1836.2.15 / MA1836.2.2 / MA1836.2.20 / MA1836.2.4 / MA1836.2.7 MA1836.1.12 MA1836.1.14 MA1836.1.17 MA1836.1.4 MA1836.1.8 MA1836.2.1 / MA1836.2.16 MA1836.2.10 / MA1836.2.19 / MA1836.2.3 / MA1836.2.6 MA1836.2.12 MA1836.2.13 MA1836.2.14 MA1836.2.17 / MA1836.2.18 / MA1836.2.5 MA1836.2.8 MA1836.2.9 |
| Publications: | Erdman S.E, Chen H.J, Burtis K.C. Functional and genetic characterization of the oligomerization and DNA binding properties of the Drosophila doublesex proteins. Genetics 144:1639-52 (1996). [Pubmed] Bergman C.M, Carlson J.W, Celniker S.E. Drosophila DNase I footprint database: a systematic genome annotation of transcription factor binding sites in the fruitfly, Drosophila melanogaster. Bioinformatics (Oxford, England) 21:1747-9 (2005). [Pubmed] |
| Related annotations: | PaperBLAST |
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