Transcription Factor
| Accessions: | ETV7_TF1 (HumanTF2 1.0), ETV7_TF2 (HumanTF2 1.0) |
| Names: | ETS translocation variant 7, ETS-related protein Tel2, ETV7, ETV7_HUMAN, Tel-related Ets factor, Transcription factor ETV7, Transcription factor Tel-2 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF2 1.0 1 1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Uniprot: | Q9Y603 |
| Notes: | Ensembl ID: ENSG00000010030; Construct type: TF1(SBP); TF family: ETS; Clone source: Megaman, Ensembl ID: ENSG00000010030; Construct type: TF2(3xFLAG); TF family: ETS; Clone source: Megaman |
| Length: | 321 |
| Pfam Domains: | 39-108 Sterile alpha motif (SAM)/Pointed domain 217-298 Ets-domain |
| Sequence: (in bold interface residues) | 1 SPISPVAAMPPLGTHVQARCEAQINLLGEGGICKLPGRLRIQPALWSREDVLHWLRWAEQ 60 61 EYSLPCTAEHGFEMNGRALCILTKDDFRHRAPSSGDVLYELLQYIKTQRRALVCGPFFGG 120 121 IFRLKTPTQHSPVPPEEVTGPSQMDTRRGHLLQPPDPGLTSNFGHLDDPGLARWTPGKEE 180 181 SLNLCHCAELGCRTQGVCSFPAMPQAPIDGRIADCRLLWDYVYQLLLDTRYEPYIKWEDK 240 241 DAKIFRVVDPNGLARLWGNHKNRVNMTYEKMSRALRHYYKLNIIKKEPGQKLLFRFLKTP 300 301 GKMVQDKHSHLEPLESQEQDR |
| Interface Residues: | 269, 270, 272, 273, 274, 276, 277, 291 |
| 3D-footprint Homologues: | 1dux_F, 7jsa_J, 3zp5_A, 8ee9_F, 4mhg_A, 2stt_A, 4uno_A, 3jtg_A, 4l18_B, 4lg0_B, 1yo5_C, 4bqa_A, 1awc_A, 4iri_A, 1bc8_C |
| Binding Motifs: | ELK1_ETV7 amsCGGAMGGATdTCCGgyt ERF_ETV7 rsmGGAmGGAykTCCkss ETV2_ETV7 asmGGAMGGAydTCCksb ETV5_ETV7 rvGGAmGGATgTCCkbg ETV7_1 rgscGGAARTr ETV7_2 gcGGAAgTryTTCCks ETV7_2_3 yryTTCCGGGAArtr ETV7_TBX21_1 mCCGGAAryvrahtTcaCRCct ETV7_TBX21_2 mCCGGAAryrmbhTCaCACcy FLI1_ETV7 rsmGGAmGGAtdTCCgsb FOXO1_ETV7 vwmAACAGGAmryrcTTCCks GCM1_ETV7_1 atrmGGGCGGAArydyTTCCbby GCM1_ETV7_2 mTrmGGGCGGAaGtgkdtCCssy HOXB2_ETV7_1 TrATgrcsmGGAAryrCTTCCgs HOXB2_ETV7_2 rscGGAArtavsymATTAr HOXB2_ETV7_2_3 rsmGGAAGTrrrgymrTYAg RFX3_ETV7 ascmGGAAgyryTTCCyTrgCaACs TEAD4_ETV7 rGAATGCGGAAGyrytTCCg TFAP2C_ETV7 sCYbsrGGssrcGGAAgyvytTCCks |
| Publications: | Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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