Transcription Factor
| Accessions: | CREB3L1_DBD (HumanTF 1.0), CREB3L1 (HT-SELEX2 May2017) |
| Names: | B2RA75_HUMAN, cDNA, FLJ94739, highly similar to Homo sapiens cAMP responsive element binding protein 3-like 1, CREB3L1, ENSG00000157613 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HT-SELEX2 May2017 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | B2RA75 |
| Notes: | Ensembl ID: ENSG00000157613; DNA-binding domain sequence; TF family: bZIP; Clone source: Gene synthesis, TF family: bZIP experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: bZIP experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: bZIP experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 2, TF family: bZIP experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3, TF family: bZIP experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4 |
| Length: | 143 |
| Pfam Domains: | 62-124 bZIP transcription factor 65-115 Basic region leucine zipper |
| Sequence: (in bold interface residues) | 1 PSSPVRPMARSSTAISTSPLLTAPHKLQGTSGPLLLTEEEKRTLIAEGYPIPTKLPLTKA 60 61 EEKALKRVRRKIKNKISAQESRRKKKEYVECLEKKVETFTSENNELWKKVETLENANRTL 120 121 LQQLQKLQTLVTNKISRPYKMAA |
| Interface Residues: | 70, 71, 74, 75, 77, 78, 81, 82 |
| 3D-footprint Homologues: | 1nwq_C, 7x5e_F, 6mg1_B, 2dgc_A, 5t01_B, 1dh3_C, 5vpe_D |
| Binding Motifs: | CREB3L1_DBD_1 rTGCCACGTCAyCa CREB3L1_DBD_2 tGCCACGTGGCa CREB3L1_10 yGCCACGTCAyc CREB3L1_11 yGCcACGTgGCr CREB3L1_12 yGCCACGTrkrCv CREB3L1_4 yGCCACGTCAyc CREB3L1_5 yGCCACGTGGCa CREB3L1_6 rtGCCACGTgkrcr CREB3L1_methyl_1 yGCCACrTCAyc CREB3L1_methyl_2 yGCCACGTGGCr CREB3L1_methyl_3 ryGCCACGyGtrCr CREB3L1_methyl_7 yGCCACrTCAyC CREB3L1_methyl_8 yGCCACGTGGCr CREB3L1_methyl_9 yGCCACryGTrCr |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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