Transcription Factor

Accessions: P50458 (JASPAR 2024)
Names: Homeobox protein LH-2, LHX2_HUMAN, LIM homeobox protein 2, LIM/homeobox protein Lhx2
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: P50458
Length: 406
Pfam Domains: 53-110 LIM domain
115-170 LIM domain
257-319 Homeobox KN domain
267-323 Homeobox domain
Sequence:
(in bold interface residues)
1 MLFHSLSGPEVHGVIDEMDRRAKSEAPAISSAIDRGDTETTMPSISSDRAALCAGCGGKI 60
61 SDRYYLLAVDKQWHMRCLKCCECKLNLESELTCFSKDGSIYCKEDYYRRFSVQRCARCHL 120
121 GISASEMVMRARDLVYHLNCFTCTTCNKMLTTGDHFGMKDSLVYCRLHFEALLQGEYPAH 180
181 FNHADVAAAAAAAAAAKSAGLGAAGANPLGLPYYNGVGTVQKGRPRKRKSPGPGADLAAY 240
241 NAALSCNENDAEHLDRDQPYPSSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLA 300
301 QKTGLTKRVLQVWFQNARAKFRRNLLRQENTGVDKSTDAALQTGTPSGPASELSNASLSP 360
361 SSTPTTLTDLTSPTLPTVTSVLTSVPGNLEGHEPHSPSQTTLTNLF
Interface Residues: 266, 267, 268, 269, 270, 308, 309, 311, 312, 315, 316, 319, 320, 322, 323, 333, 336
3D-footprint Homologues: 3d1n_M, 1fjl_B, 3cmy_A, 1ig7_A, 6a8r_A, 1puf_A, 5zfz_A, 2h1k_B, 6fqp_B, 2lkx_A, 2r5y_A, 1zq3_P, 1nk2_P, 6m3d_C, 1jgg_B, 3lnq_A, 7q3o_C, 6es3_K, 2ld5_A, 1puf_B, 5zjt_E, 2hdd_A, 1b72_A, 5hod_A, 3rkq_B, 2hos_A, 5jlw_D, 4cyc_A, 2d5v_B, 4xrs_G, 3l1p_A, 7psx_B, 4j19_B, 3a01_E, 5flv_I, 7xrc_C, 2xsd_C, 1e3o_C, 1le8_A, 4qtr_D, 1le8_B, 6fqq_E, 1du0_A, 8g87_X, 4xrm_B
Binding Motifs: MA0700.1 rCTAATTArc
MA0700.2 wwcCAATTAww
MA0700.3 CAATTA
Binding Sites: MA0700.3.18 / MA0700.3.19 / MA0700.3.2 / MA0700.3.4
MA0700.2.1
MA0700.2.10 / MA0700.2.7
MA0700.2.11
MA0700.2.12 / MA0700.2.8
MA0700.2.13 / MA0700.2.9
MA0700.2.10 / MA0700.2.14
MA0700.2.15
MA0700.2.16
MA0700.2.17
MA0700.2.11 / MA0700.2.18
MA0700.2.12 / MA0700.2.19
MA0700.2.2
MA0700.2.13 / MA0700.2.20
MA0700.2.2 / MA0700.2.3
MA0700.2.3 / MA0700.2.4
MA0700.2.5
MA0700.2.4 / MA0700.2.6
MA0700.2.7
MA0700.2.6 / MA0700.2.8
MA0700.2.9
MA0700.2.14
MA0700.2.15
MA0700.2.16
MA0700.2.17
MA0700.2.18
MA0700.2.19
MA0700.2.20
MA0700.2.5
MA0700.3.12
MA0700.3.1 / MA0700.3.10 / MA0700.3.11 / MA0700.3.13 / MA0700.3.14 / MA0700.3.15 / MA0700.3.17 / MA0700.3.20 / MA0700.3.6 / MA0700.3.7 / MA0700.3.8 / MA0700.3.9
MA0700.3.16
MA0700.3.3
MA0700.3.5
Publications: Noyes M.B, Christensen R.G, Wakabayashi A, Stormo G.D, Brodsky M.H, Wolfe S.A. Analysis of homeodomain specificities allows the family-wide prediction of preferred recognition sites. Cell 133:1277-89 (2008). [Pubmed]

Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Related annotations: PaperBLAST

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