Transcription Factor

						

			
Accessions: HNF1B_HUMAN (HOCOMOCO 10), P35680 (JASPAR 2024)

			
Names: Hepatocyte nuclear factor 1-beta, HNF-1-beta, HNF-1B, HNF1B_HUMAN, Homeoprotein LFB3, TCF-2, Transcription factor 2, Variant hepatic nuclear factor 1, vHNF1
Organisms: Homo sapiens, Mus musculus
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 557
Pfam Domains:     1-182 Hepatocyte nuclear factor 1 (HNF-1), N terminus
  232-305 Homeobox domain
  314-551 Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus
Sequence: 
(in bold interface residues)		   1 MVSKLTSLQQELLSALLSSGVTKEVLVQALEELLPSPNFGVKLETLPLSPGSGAEPDTKP   60
  61 VFHTLTNGHAKGRLSGDEGSEDGDDYDTPPILKELQALNTEEAAEQRAEVDRMLSEDPWR  120
 121 AAKMIKGYMQQHNIPQREVVDVTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREIL  180
 181 RQFNQTVQSSGNMTDKSSQDQLLFLFPEFSQQSHGPGQSDDACSEPTNKKMRRNRFKWGP  240
 241 ASQQILYQAYDRQKNPSKEEREALVEECNRAECLQRGVSPSKAHGLGSNLVTEVRVYNWF  300
 301 ANRRKEEAFRQKLAMDAYSSNQTHSLNPLLSHGSPHHQPSSSPPNKLSGVRYSQQGNNEI  360
 361 TSSSTISHHGNSAMVTSQSVLQQVSPASLDPGHNLLSPDGKMISVSGGGLPPVSTLTNIH  420
 421 SLSHHNPQQSQNLIMTPLSGVMAIAQSLNTSQAQSVPVINSVAGSLAALQPVQFSQQLHS  480
 481 PHQQPLMQQSPGSHMAQQPFMAAVTQLQNSHMYAHKQEPPQYSHTSRFPSAMVVTDTSSI  540
 541 STLTNMSSSKQCPLQAW
Interface Residues: 146, 147, 148, 149, 151, 152, 158, 159, 232, 235, 297, 298, 301, 302, 305
3D-footprint Homologues: 2h8r_B, 1ic8_B, 1fjl_B, 4j19_B
Binding Motifs: MA0153.1 yyAATrwTTAAC
MA0153.2 GTTAATsATTAAy
HNF1B_HUMAN.H10MO.B|M01224 rgTTAATrwTTaAc
Binding Sites: MA0153.1.1
MA0153.1.2
MA0153.1.3
MA0153.1.4
MA0153.1.5
MA0153.1.6
MA0153.1.7
MA0153.1.8
MA0153.1.9
			
Publications: Portales-Casamar E, Kirov S, Lim J, Lithwick S, Swanson M.I, Ticoll A, Snoddy J, Wasserman W.W. PAZAR: a framework for collection and dissemination of cis-regulatory sequence annotation. Genome biology 8:R207 (2007). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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