Transcription Factor
| Accessions: | T161871_1.02 (CISBP 1.02), UP00331A (UniPROBE 20160601), P38140 (JASPAR 2024) |
| Names: | ERT1, T161871_1.02;, Putative 60.3 kDa transcriptional regulatory protein in PRP5-THI2 intergenic region, YBR1622, Ybr239c, ERT1_YEAST, Ethanol regulator of translation 1, Transcription activator of gluconeogenesis ERT1 |
| Organisms: | Saccharomyces cerevisiae |
| Libraries: | CISBP 1.02 1, UniPROBE 20160601 2, JASPAR 2024 3 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Description: | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR239C is not an essential gene |
| Notes: | experiment type:PBM, family:Zinc cluster |
| Length: | 529 |
| Pfam Domains: | 39-77 Fungal Zn(2)-Cys(6) binuclear cluster domain 411-527 PAS fold |
| Sequence: (in bold interface residues) | 1 MCTPDENDYKTSTDPDTSANTNHTLEKKKRKKRKNTNVACVNCSRLHVSCEAKRPCLRCI 60 61 SKGLTATCVDAPRKKSKYLAGIPNRELPMNIQPDLPPRKIMIPIYNNSSNSSLNVNNMGE 120 121 QQKFTSPQHIVHKAKFLSNAADSEYSILSNIIYQDTLSNKIPIDILYSNTNSTSNSTIGN 180 181 SSNNSPTGTNTSPEETEMEKIRQLYSEQRANIPPHPYPSSNQNVYSILLGPNSAKIVASQ 240 241 VNLFANHFPLVPVDSADNSLNFKRLLPRDPSEKSSQINWDSSINQYYLNSETVTFPELAI 300 301 PLKRRKNHLVSVSLESCSPDAANIKSNVEWEHSLRYSTPMEIYTSINAPFSHTPGFHHLL 360 361 VYLKHRFNQQDLVKMCRSIAEFRPIFIACSVTLTEEDMIFMEQCYQRTLLEYVKFIAQIG 420 421 TPTCIWRRNGQISYVNEEFEILCGWTREELLNKMTFIVEIMDDESVRDYFKTLSKVAYRD 480 481 FRGSEKMKVCRLLSPIKGKIIHCCCMWTLKRDVSGLPLMILGNFMPILN |
| Interface Residues: | 35, 46, 47, 48, 75, 78, 80, 103, 105, 110, 114, 116, 181, 184, 191, 201, 203, 260, 305, 306, 320, 322, 323, 325 |
| 3D-footprint Homologues: | 6o19_A, 6gys_C, 1zme_D, 3uvf_B, 7pik_B, 4dkj_A |
| Binding Motifs: | UP00331A_1 mrmwwdTTCCGGAACawmhr M1772_1.02 rTTCCGrw MA0420.1 ayCGGAAy MA0420.2 yCGGAAy |
| Binding Sites: | AATCGGAA ACCGGAAC AGTTCCGA ATCGGAAC ATCGGAAT ATTCCGGA CACCGGAA CATCGGAA CCGGAACA CCGGAACC CCGGAACG CGTTCCGA GATCGGAA GGTTCCGA GTCGGAAC GTTCCGGA TATCGGAA TCGGAACA TTCCGGAA TATTCCGA |
| Publications: | *Zhu C, *Byers K, *McCord RP, Shi Z, Berger MF, Newburger D, Saulrieta K, Smith Z, Shah M, Radhakrishnan M, Philippakis AA, Hu Y, De Masi F, Pacek M, Rolfs A , Murthy TVS, LaBaer J, Bulyk ML. High-Resolution DNA Binding Specificity Analysis of Yeast Transcription Factors. Genome Research. Epub January 21, 2009, doi:10.1101/gr.090233.108 (*co-1st authors). [Pubmed] Badis G, Chan E.T, van Bakel H, Pena-Castillo L, Tillo D, Tsui K, Carlson C.D, Gossett A.J, Hasinoff M.J, Warren C.L, Gebbia M, Talukder S, Yang A, Mnaimneh S, Terterov D, Coburn D, Li Yeo A, Yeo Z.X, Clarke N.D, Lieb J.D, Ansari A.Z, Nislow C, Hughes T.R. A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Molecular cell 32:878-87 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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