Transcription Factor

						

			
Accessions: PAX7 (SMILE-seq 1.0)

			
Names: HuP1, Paired box protein Pax-7, PAX7, PAX7_HUMAN
Organisms: Homo sapiens
Libraries: SMILE-seq 1.0 1
1 Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed]
Uniprot: P23759
Notes: TF family: PAX+Homeodomain
Length: 517
Pfam Domains:    34-159 'Paired box' domain
  216-272 Homeobox domain
  239-269 Homeobox KN domain
  343-383 Paired box protein 7 
Sequence: 
(in bold interface residues)		   1 MAALPGTVPRMMRPAPGQNYPRTGFPLEVSTPLGQGRVNQLGGVFINGRPLPNHIRHKIV   60
  61 EMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPRQVATPDVEKKIEE  120
 121 YKRENPGMFSWEIRDRLLKDGHCDRSTVPSVSSISRVLRIKFGKKEEEDEADKKEDDGEK  180
 181 KAKHSIDGILGDKGNRLDEGSDVESEPDLPLKRKQRRSRTTFTAEQLEELEKAFERTHYP  240
 241 DIYTREELAQRTKLTEARVQVWFSNRRARWRKQAGANQLAAFNHLLPGGFPPTGMPTLPP  300
 301 YQLPDSTYPTTTISQDGGSTVHRPQPLPPSTMHQGGLAAAAAAADTSSAYGARHSFSSYS  360
 361 DSFMNPAAPSNHMNPVSNGLSPQVMSILGNPSAVPPQPQADFSISPLHGGLDSATSISAS  420
 421 CSQRADSIKPGDSLPTSQAYCPPTYSTTGYSVDPVAGYQYGQYGQSECLVPWASPVPIPS  480
 481 PTPRASCLFMESYKVVSGWGMSISQMEKLKSSQMEQF
Interface Residues: 47, 79, 80, 82, 84, 85, 101, 104, 107, 150, 151, 152, 153, 155, 156, 159, 215, 216, 217, 218, 219, 257, 258, 260, 261, 264, 265, 267, 268, 269, 271, 272
3D-footprint Homologues: 1pdn_C, 6pax_A, 1k78_A, 4j19_B, 3cmy_A, 6a8r_A, 3d1n_M, 2h1k_B, 1fjl_B, 1puf_A, 5zfz_A, 6fqp_B, 1ig7_A, 1jgg_B, 1zq3_P, 6m3d_C, 2lkx_A, 1nk2_P, 3lnq_A, 7q3o_C, 2ld5_A, 6es3_K, 5zjt_E, 2hos_A, 5hod_A, 3rkq_B, 5jlw_D, 1au7_A, 4cyc_A, 4xrs_G, 3l1p_A, 1b72_A, 3a01_E, 2hdd_A, 5flv_I, 2r5y_A, 1puf_B, 7psx_B, 1le8_A, 2xsd_C, 1e3o_C, 7xrc_C, 1du0_A, 4qtr_D, 1o4x_A, 6fqq_E, 1le8_B, 4xrm_B, 1k61_B, 1mnm_C, 8g87_X, 2ypa_A
Binding Motifs: PAX7 aasCGTrACkAAT
			
Publications: Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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