Transcription Factor
| Accessions: | T139027_1.02 (CISBP 1.02), P48743 (JASPAR 2024) |
| Names: | RFX1, T139027_1.02;, RFX1_YEAST |
| Organisms: | Saccharomyces cerevisiae, Homo sapiens |
| Libraries: | CISBP 1.02 1, JASPAR 2024 2 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | experiment type:PBM, family:RFX |
| Length: | 811 |
| Pfam Domains: | 278-350 RFX DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MVIFKERKPTENLFTRKIPAKYFIFSPSFLSVHYFEFYLPMSGDNNIEPTSRGSNDNSNG 60 61 PSNGSSVNSNRYSLNAPKYSSQPPPASHTYLPPMSVNIPPIASKSSSIYSLLHQSSPRPE 120 121 TPNPILPPLIGSGPGSHKPSPTPTQPPAQPATQRQPATYSVYPASISLNRSNSSAYPLSF 180 181 KSEETLNNNPPTAAKRTNTFPSIPSSTKKQKTSQEKRISSISRRNTQEIIAKQIAENNKS 240 241 KTIEEYAQIVKHAEIKVLSMDSQNTSKAALQLAEQNRERERQVFALLWLMKNCKSQHDSY 300 301 VPRGKIFAQYASSCSQNNLKPLSQASLGKLIRTVFPDLTTRRLGMRGQSKYHYCGLKLTV 360 361 NESGSVSLNNNNASLSLVHNNDPISPLSSPSPSSPSPQVPNVSSPFSLNRKSLSRTGSPV 420 421 KQSSNDNPNEPELESQHPNETEANKLDSLPPAANNPTGTLSSDELTFTHDLIEKVFNCND 480 481 KLSDNYNTQILSNTEHPLLTSYKLDFPKIPAGVLPTDTDSDVISSLESLYHIHCNSVYEC 540 541 IKFLKSDNISNALFFSNSNSISPTMFNLFISEPLIDWVTKCDLITYTGLIKFFSQFIIHS 600 601 NEISDSIIQKLESMIKLLPEQINKAVLELPKALVQRKLSIINNFTKLVKKLIKLLKFILN 660 661 FLKSFPIFKSGMNNDWKNIVNLDDILEMMINEDDTNSETNTIMQHLQGFCQVFVTKFLNS 720 721 SMSVSNDPSVSIECKSLNEMIKDFCSFISLQSKFSCLKLIDCSTRFRNAIIGDISLKSNE 780 781 NLLSWLFLNNVMGQLLNYCFEVMKFVNGLKV |
| Interface Residues: | 106, 107, 109, 129, 132, 139, 150, 152, 325, 329, 342, 346, 351 |
| 3D-footprint Homologues: | 7pik_B, 1dp7_P |
| Binding Motifs: | M1536_1.02 vTrGCAACsa MA0365.1 sGTTRCyA MA0509.2 ykGTTGCyAtGGma MA0509.3 sGTTGCCATGGyAACs MA0365.2 GTTRCyA |
| Binding Sites: | MA0509.2.1 MA0509.2.10 / MA0509.3.3 MA0509.2.11 MA0509.2.12 MA0509.2.13 / MA0509.3.4 MA0509.2.14 / MA0509.3.5 MA0509.2.15 MA0509.2.16 MA0509.2.17 MA0509.2.18 MA0509.2.19 / MA0509.3.6 MA0509.2.2 / MA0509.2.3 MA0509.2.20 / MA0509.3.7 MA0509.2.4 MA0509.2.5 / MA0509.2.6 / MA0509.3.1 / MA0509.3.2 MA0509.2.7 MA0509.2.8 MA0509.2.9 MA0509.3.19 MA0509.3.10 / MA0509.3.9 MA0509.3.12 MA0509.3.13 MA0509.3.14 MA0509.3.11 MA0509.3.15 MA0509.3.16 MA0509.3.17 MA0509.3.18 MA0509.3.20 MA0509.3.8 |
| Publications: | Badis G, Chan E.T, van Bakel H, Pena-Castillo L, Tillo D, Tsui K, Carlson C.D, Gossett A.J, Hasinoff M.J, Warren C.L, Gebbia M, Talukder S, Yang A, Mnaimneh S, Terterov D, Coburn D, Li Yeo A, Yeo Z.X, Clarke N.D, Lieb J.D, Ansari A.Z, Nislow C, Hughes T.R. A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Molecular cell 32:878-87 (2008). [Pubmed] Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Related annotations: | PaperBLAST |
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