Transcription Factor

Accessions: JUNB_HUMAN (HOCOMOCO 10), P17275 (JASPAR 2024)
Names: JUNB_HUMAN, Transcription factor AP-1 subunit JunB, Transcription factor JunB
Organisms: Homo sapiens
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 347
Pfam Domains: 5-257 Jun-like transcription factor
266-329 bZIP transcription factor
273-326 Basic region leucine zipper
Sequence:
(in bold interface residues)
1 MCTKMEQPFYHDDSYTATGYGRAPGGLSLHDYKLLKPSLAVNLADPYRSLKAPGARGPGP 60
61 EGGGGGSYFSGQGSDTGASLKLASSELERLIVPNSNGVITTTPTPPGQYFYPRGGGSGGG 120
121 AGGAGGGVTEEQEGFADGFVKALDDLHKMNHVTPPNVSLGATGGPPAGPGGVYAGPEPPP 180
181 VYTNLSSYSPASASSGGAGAAVGTGSSYPTTTISYLPHAPPFAGGHPAQLGLGRGASTFK 240
241 EEPQTVPEARSRDATPPVSPINMEDQERIKVERKRLRNRLAATKCRKRKLERIARLEDKV 300
301 KTLKAENAGLSSTAGLLREQVAQLKQKVMTHVSNGCQLLLGVKGHAF
Interface Residues: 263, 264, 267, 268, 274, 275, 277, 278, 279, 281, 282, 285, 286, 289
3D-footprint Homologues: 5i50_B, 7x5e_E, 2wt7_B, 1skn_P, 7x5e_F, 4eot_A, 2wt7_A, 1gd2_G, 6mg1_B, 5vpe_C, 5vpe_D, 2dgc_A, 5t01_B
Binding Motifs: MA0490.1 grrTGAsTCAk
MA1140.2 gATGACGTCAyc
JUNB_HUMAN.H10MO.C|M01281 ggrTGAGTCAy
MA1132.1 kaTGACkCAt
MA1133.1 krTGACGTCATb
MA1134.1 krTGAsTCAymv
MA1135.1 krTGAsTCAy
MA1136.1 rTGACGTCAy
MA1137.1 ykrTGAcTMAtmc
MA1138.1 krTGAsTCAy
MA1139.1 krTGACGTCAym
MA1140.1 rTkACGTmAy
MA0490.2 wdATGACTCATwh
MA0490.3 ATGACTCAT
MA1132.2 aTGACkCA
MA1133.2 krTGACGTCAT
MA1134.2 rTGAsTCAy
MA1137.2 rTGAcTMAt
MA1138.2 rTGAsTCAy
MA1139.2 rTGACGTCAy
MA1140.3 ATGACGTCAyc
Binding Sites: MA0490.1.1
MA0490.1.10
MA0490.1.11
MA0490.1.12
MA0490.1.13
MA0490.1.14
MA0490.1.15
MA0490.1.16
MA0490.1.17
MA0490.1.18
MA0490.1.19
MA0490.1.2
MA0490.1.20
MA0490.1.3
MA0490.1.4
MA0490.1.5
MA0490.1.6
MA0490.1.7
MA0490.1.8
MA0490.1.9
MA0490.2.1
MA0490.2.8
MA0490.2.4 / MA0490.2.9
MA0490.2.10
MA0490.2.11 / MA0490.2.5
MA0490.2.2
MA0490.2.2 / MA0490.2.4
MA0490.2.12 / MA0490.2.6
MA0490.2.13
MA0490.2.14 / MA0490.2.7
MA0490.2.15
MA0490.2.16
MA0490.2.17 / MA0490.2.8
MA0490.2.18 / MA0490.2.9
MA0490.2.10 / MA0490.2.19
MA0490.2.11 / MA0490.2.20
MA0490.2.3
MA0490.2.5
MA0490.2.6
MA0490.2.3 / MA0490.2.7
MA0490.2.12
MA0490.2.13
MA0490.2.14
MA0490.2.15
MA0490.2.16
MA0490.2.17
MA0490.2.18
MA0490.2.19
MA0490.2.20
MA0490.3.1
MA0490.3.8
MA0490.3.7
MA0490.3.9
MA0490.3.10
MA0490.3.11 / MA0490.3.18
MA0490.3.12
MA0490.3.13
MA0490.3.2
MA0490.3.5 / MA0490.3.6
MA0490.3.4
MA0490.3.14 / MA0490.3.17
MA0490.3.15 / MA0490.3.16
MA0490.3.19
MA0490.3.20
MA0490.3.3
Publications: Li M, Ge Q, Wang W, Wang J, Lu Z. c-Jun binding site identification in K562 cells. Journal of genetics and genomics = Yi chuan xue bao 38:235-42 (2011). [Pubmed]

Colin L, Vandenhoudt N, de Walque S, Van Driessche B, Bergamaschi A, Martinelli V, Cherrier T, Vanhulle C, Guiguen A, David A, Burny A, Herbein G, Pancino G, Rohr O, Van Lint C. The AP-1 binding sites located in the pol gene intragenic regulatory region of HIV-1 are important for viral replication. PloS one 6:e19084 (2011). [Pubmed]

Shaulian E, Karin M. AP-1 as a regulator of cell life and death. Nat Cell Biol : (2002). [Pubmed]

Song X, Tao YG, Deng XY, Jin X, Tan YN, Tang M, Wu Q, Lee LM, Cao Y. Heterodimer formation between c-Jun and Jun B proteins mediated by Epstein-Barr virus encoded latent membrane protein 1. Cell Signal 16:1153-62 (2004). [Pubmed]

Ameyar M, Wisniewska M, Weitzman JB. A role for AP-1 in apoptosis: the case for and against. Biochimie 85:747-52 (2003). [Pubmed]
Related annotations: PaperBLAST

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