Transcription Factor

Accessions: STAT1_HUMAN (HOCOMOCO 10), P42224 (JASPAR 2024), Q53XW4 (JASPAR 2024)
Names: Signal transducer and activator of transcription 1-alpha/beta, STAT1_HUMAN, Transcription factor ISGF-3 components p91/p84
Organisms: Homo sapiens
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 750
Pfam Domains: 2-121 STAT protein, protein interaction domain
137-315 STAT protein, all-alpha domain
317-567 STAT protein, DNA binding domain
578-638 SH2 domain
715-739 STAT1 TAZ2 binding domain
Sequence:
(in bold interface residues)
1 MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDL 60
61 LSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQ 120
121 RFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNR 180
181 EHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWK 240
241 RRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQV 300
301 LWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKV 360
361 KVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTN 420
421 EGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAE 480
481 PRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWT 540
541 RFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFL 600
601 LRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIP 660
661 ENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTT 720
721 DNLLPMSPEEFDEVSRIVGSVEFDSMMNTV
Interface Residues: 336, 421, 459, 460, 461, 462, 463, 588
3D-footprint Homologues: 1bf5_A, 4y5w_B, 1bg1_A, 8gh6_A
Binding Motifs: MA0137.3 tTTCyrGGAAa
STAT1_HUMAN.H10MO.A|M01539 yCmtTTCChgGAAAwcwcaTkm
MA0137.1 rGRAAayGAAACTr
MA0137.2 cayTTCChrGAAryc
MA0137.4 TTCyrGGAA
Binding Sites: MA0137.1.1
MA0137.1.10
MA0137.1.11
MA0137.1.12
MA0137.1.13
MA0137.1.14
MA0137.1.15
MA0137.1.2
MA0137.1.3
MA0137.1.4
MA0137.1.5
MA0137.1.6 / MA0137.1.7
MA0137.1.8
MA0137.1.9
MA0137.2.1
MA0137.2.10
MA0137.2.11
MA0137.2.12
MA0137.2.13
MA0137.2.14
MA0137.2.15
MA0137.2.16
MA0137.2.17
MA0137.2.18
MA0137.2.19
MA0137.2.2
MA0137.2.20
MA0137.2.3
MA0137.2.4
MA0137.2.5
MA0137.2.6
MA0137.2.7
MA0137.2.8
MA0137.2.9
MA0137.3.1
MA0137.3.10
MA0137.3.11 / MA0137.3.19
MA0137.3.12
MA0137.3.13
MA0137.3.14 / MA0137.3.16
MA0137.3.15
MA0137.3.17
MA0137.3.18
MA0137.3.2
MA0137.3.20
MA0137.3.3
MA0137.3.4
MA0137.3.5
MA0137.3.6
MA0137.3.7
MA0137.3.8
MA0137.3.9
MA0137.4.1
MA0137.4.10
MA0137.4.11
MA0137.4.12 / MA0137.4.18
MA0137.4.13 / MA0137.4.5
MA0137.4.14
MA0137.4.15
MA0137.4.16
MA0137.4.17
MA0137.4.19
MA0137.4.2
MA0137.4.20
MA0137.4.3
MA0137.4.4
MA0137.4.6
MA0137.4.7
MA0137.4.8
MA0137.4.9
Publications: Robertson G, Hirst M, Bainbridge M, Bilenky M, Zhao Y, Zeng T, Euskirchen G, Bernier B, Varhol R, Delaney A, Thiessen N, Griffith O.L, He A, Marra M, Snyder M, Jones S. Genome-wide profiles of STAT1 DNA association using chromatin immunoprecipitation and massively parallel sequencing. Nature methods 4:651-7 (2007). [Pubmed]
Related annotations: PaperBLAST

Disclaimer and license

These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.