Transcription Factor
Accessions: | STAT1_HUMAN (HOCOMOCO 10), P42224 (JASPAR 2024), Q53XW4 (JASPAR 2024) |
Names: | Signal transducer and activator of transcription 1-alpha/beta, STAT1_HUMAN, Transcription factor ISGF-3 components p91/p84 |
Organisms: | Homo sapiens |
Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
Length: | 750 |
Pfam Domains: | 2-121 STAT protein, protein interaction domain 137-315 STAT protein, all-alpha domain 317-567 STAT protein, DNA binding domain 578-638 SH2 domain 715-739 STAT1 TAZ2 binding domain |
Sequence: (in bold interface residues) | 1 MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDL 60 61 LSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQ 120 121 RFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNR 180 181 EHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWK 240 241 RRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQV 300 301 LWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKV 360 361 KVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTN 420 421 EGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAE 480 481 PRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWT 540 541 RFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFL 600 601 LRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIP 660 661 ENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTT 720 721 DNLLPMSPEEFDEVSRIVGSVEFDSMMNTV |
Interface Residues: | 336, 421, 459, 460, 461, 462, 463, 588 |
3D-footprint Homologues: | 1bf5_A, 4y5w_B, 1bg1_A, 8gh6_A |
Binding Motifs: | MA0137.3 tTTCyrGGAAa STAT1_HUMAN.H10MO.A|M01539 yCmtTTCChgGAAAwcwcaTkm MA0137.1 rGRAAayGAAACTr MA0137.2 cayTTCChrGAAryc MA0137.4 TTCyrGGAA |
Binding Sites: | MA0137.1.1 MA0137.1.10 MA0137.1.11 MA0137.1.12 MA0137.1.13 MA0137.1.14 MA0137.1.15 MA0137.1.2 MA0137.1.3 MA0137.1.4 MA0137.1.5 MA0137.1.6 / MA0137.1.7 MA0137.1.8 MA0137.1.9 MA0137.2.1 MA0137.2.10 MA0137.2.11 MA0137.2.12 MA0137.2.13 MA0137.2.14 MA0137.2.15 MA0137.2.16 MA0137.2.17 MA0137.2.18 MA0137.2.19 MA0137.2.2 MA0137.2.20 MA0137.2.3 MA0137.2.4 MA0137.2.5 MA0137.2.6 MA0137.2.7 MA0137.2.8 MA0137.2.9 MA0137.3.1 MA0137.3.10 MA0137.3.11 / MA0137.3.19 MA0137.3.12 MA0137.3.13 MA0137.3.14 / MA0137.3.16 MA0137.3.15 MA0137.3.17 MA0137.3.18 MA0137.3.2 MA0137.3.20 MA0137.3.3 MA0137.3.4 MA0137.3.5 MA0137.3.6 MA0137.3.7 MA0137.3.8 MA0137.3.9 MA0137.4.1 MA0137.4.10 MA0137.4.11 MA0137.4.12 / MA0137.4.18 MA0137.4.13 / MA0137.4.5 MA0137.4.14 MA0137.4.15 MA0137.4.16 MA0137.4.17 MA0137.4.19 MA0137.4.2 MA0137.4.20 MA0137.4.3 MA0137.4.4 MA0137.4.6 MA0137.4.7 MA0137.4.8 MA0137.4.9 |
Publications: | Robertson G, Hirst M, Bainbridge M, Bilenky M, Zhao Y, Zeng T, Euskirchen G, Bernier B, Varhol R, Delaney A, Thiessen N, Griffith O.L, He A, Marra M, Snyder M, Jones S. Genome-wide profiles of STAT1 DNA association using chromatin immunoprecipitation and massively parallel sequencing. Nature methods 4:651-7 (2007). [Pubmed] |
Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.