Transcription Factor
| Accessions: | IRF4_HUMAN (HOCOMOCO 10), Q15306 (JASPAR 2024) |
| Names: | Interferon regulatory factor 4, IRF-4, IRF4_HUMAN, LSIRF, Lymphocyte-specific interferon regulatory factor, Multiple myeloma oncogene 1, NF-EM5 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 451 |
| Pfam Domains: | 23-129 Interferon regulatory factor transcription factor 249-417 Interferon-regulatory factor 3 |
| Sequence: (in bold interface residues) | 1 MNLEGGGRGGEFGMSAVSCGNGKLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQ 60 61 DYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISD 120 121 PYKVYRIVPEGAKKGAKQLTLEDPQMSMSHPYTMTTPYPSLPAQQVHNYMMPPLDRSWRD 180 181 YVPDQPHPEIPYQCPMTFGPRGHHWQGPACENGCQVTGTFYACAPPESQAPGVPTEPSIR 240 241 SAEALAFSDCRLHICLYYREILVKELTTSSPEGCRISHGHTYDASNLDQVLFPYPEDNGQ 300 301 RKNIEKLLSHLERGVVLWMAPDGLYAKRLCQSRIYWDGPLALCNDRPNKLERDQTCKLFD 360 361 TQQFLSELQAFAHHGRSLPRFQVTLCFGEEFPDPQRQRKLITAHVEPLLARQLYYFAQQN 420 421 SGHFLRGYDLPEHISNPEDYHRSIRHSSIQE |
| Interface Residues: | 56, 58, 91, 95, 96, 98, 99, 102, 103 |
| 3D-footprint Homologues: | 2pi0_B, 1if1_B, 2o61_A, 2irf_L, 7oot_B |
| Binding Motifs: | MA1419.1 yCGAAACCGAAACya IRF4_HUMAN.H10MO.C|M01269 rrrrrGGAAstGArAs MA1419.2 CGAAACCGAAACya |
| Publications: | Ourthiague DR, Birnbaum H, Ortenlöf N, Vargas JD, Wollman R, Hoffmann A. Limited specificity of IRF3 and ISGF3 in the transcriptional innate-immune response to double-stranded RNA. J Leukoc Biol 98:119-28 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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