Transcription Factor
| Accessions: | ELK4_HUMAN (HOCOMOCO 10), P28324 (JASPAR 2024) |
| Names: | ELK4_HUMAN, ETS domain-containing protein Elk-4, SAP-1, Serum response factor accessory protein 1, SRF accessory protein 1 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P28324 |
| Length: | 431 |
| Pfam Domains: | 5-86 Ets-domain |
| Sequence: (in bold interface residues) | 1 MDSAITLWQFLLQLLQKPQNKHMICWTSNDGQFKLLQAEEVARLWGIRKNKPNMNYDKLS 60 61 RALRYYYVKNIIKKVNGQKFVYKFVSYPEILNMDPMTVGRIEGDCESLNFSEVSSSSKDV 120 121 ENGGKDKPPQPGAKTSSRNDYIHSGLYSSFTLNSLNSSNVKLFKLIKTENPAEKLAEKKS 180 181 PQEPTPSVIKFVTTPSKKPPVEPVAATISIGPSISPSSEETIQALETLVSPKLPSLEAPT 240 241 SASNVMTAFATTPPISSIPPLQEPPRTPSPPLSSHPDIDTDIDSVASQPMELPENLSLEP 300 301 KDQDSVLLEKDKVNNSSRSKKPKGLELAPTLVITSSDPSPLGILSPSLPTASLTPAFFSQ 360 361 TPIILTPSPLLSSIHFWSTLSPVAPLSPARLQGANTLFQFPSVLNSHGPFTLSGLDGPST 420 421 PGPFSPDLQKT |
| Interface Residues: | 57, 58, 60, 61, 62, 64, 65, 79 |
| 3D-footprint Homologues: | 4uno_A, 3jtg_A, 1dux_F, 7jsa_J, 3zp5_A, 8ee9_F, 4mhg_A, 2stt_A, 4iri_A, 1bc8_C, 4l18_B, 4lg0_B, 1yo5_C, 4bqa_A, 1awc_A |
| Binding Motifs: | MA0076.2 scrCTTCCGGy UN0118.1 gtCGKAAATsca ELK4_HUMAN.H10MO.A|M01108 accGGAARTgv MA0076.1 ACCGGAAGy MA0076.3 crCTTCCGG |
| Binding Sites: | MA0076.1.1 MA0076.1.10 MA0076.1.11 MA0076.1.12 MA0076.1.13 MA0076.1.14 MA0076.1.15 MA0076.1.16 MA0076.1.17 MA0076.1.18 MA0076.1.19 MA0076.1.2 MA0076.1.20 MA0076.1.3 MA0076.1.4 MA0076.1.5 MA0076.1.6 MA0076.1.7 MA0076.1.8 MA0076.1.9 MA0076.2.1 MA0076.2.10 MA0076.2.11 MA0076.2.12 MA0076.2.13 MA0076.2.14 MA0076.2.15 MA0076.2.16 MA0076.2.17 MA0076.2.18 MA0076.2.19 MA0076.2.2 MA0076.2.20 MA0076.2.3 MA0076.2.4 MA0076.2.5 MA0076.2.6 MA0076.2.7 MA0076.2.8 MA0076.2.9 MA0076.3.1 MA0076.3.10 MA0076.3.11 MA0076.3.12 MA0076.3.13 MA0076.3.14 MA0076.3.15 MA0076.3.16 MA0076.3.17 MA0076.3.18 MA0076.3.19 MA0076.3.2 MA0076.3.20 MA0076.3.3 MA0076.3.4 MA0076.3.5 MA0076.3.6 MA0076.3.7 MA0076.3.8 MA0076.3.9 |
| Publications: | Shore P, Sharrocks A.D. The ETS-domain transcription factors Elk-1 and SAP-1 exhibit differential DNA binding specificities. Nucleic acids research 23:4698-706 (1995). [Pubmed] |
| Related annotations: | PaperBLAST |
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