Transcription Factor
| Accessions: | UP00584B (UniPROBE 20160601) |
| Names: | Aristaless-related homeobox, ARX_L343Q, CT121, EIEE1, homeobox protein ARX, ISSX, MRX29, MRX32, MRX33, MRX36, MRX38, MRX43, MRX54, MRX76, MRX87, MRXS1, PRTS |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | homeobox protein ARX: Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate. |
| Length: | 86 |
| Pfam Domains: | 15-71 Homeobox domain |
| Sequence: (in bold interface residues) | 1 AGSDSEEGLLKRKQRRYRTTFTSYQLEEQERAFQKTHYPDVFTREELAMRLDLTEARVQV 60 61 WFQNRRAKWRKREKAGAQTHPPGLPF |
| Interface Residues: | 15, 16, 17, 18, 56, 57, 59, 60, 63, 64, 67, 68, 70, 71 |
| 3D-footprint Homologues: | 1fjl_B, 3d1n_M, 5zfz_A, 1ig7_A, 2h1k_B, 1puf_A, 6a8r_A, 3cmy_A, 1nk2_P, 1zq3_P, 6m3d_C, 1jgg_B, 3lnq_A, 2lkx_A, 7q3o_C, 6es3_K, 2ld5_A, 1au7_A, 5jlw_D, 3rkq_B, 2r5y_A, 4xrs_G, 2hos_A, 1b72_A, 4cyc_A, 5flv_I, 3l1p_A, 5zjt_E, 4j19_B, 3a01_E, 7psx_B, 5hod_A, 2hdd_A, 1le8_A, 7xrc_C, 2xsd_C, 1e3o_C, 1puf_B, 1o4x_A, 8g87_X, 1du0_A, 4qtr_D |
| Binding Motifs: | UP00584B_1 wcywgmvaysayATGTactarms UP00584B_2 wtwhtddkmTAATTAvmshwkrw |
| Binding Sites: | ACCAATTA ACTAATTA AGTAATTA ATAATTAA ATAATTAG ATAATTAT ATTAATTA CAATTATC CATACATG CCAATTAA CCAATTAG CCTAATTA CTAATTAA CTAATTAG GATAATTA GCTAATTA GTAATTAC GTTAATTA TAATATGA TAATTATA TATTAATA TGATATCA TTAATTAA ACATACAT ACATATCA ACGTACTA AGTATATA ATAACACA ATACATAC ATACATAT ATGTATTG CACATTAC CTATATAC GTATAACA GTATGATA TACACATA TACATACA TACATATA |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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