Transcription Factor
| Accessions: | ZBTB12 (humanC2H2ZF-ChIP Feb2015), Q9Y330 (JASPAR 2024) |
| Names: | ENSG00000204366, Q9Y330, ZBTB12, Protein G10, ZBT12_HUMAN, Zinc finger and BTB domain-containing protein 12 |
| Organisms: | Homo sapiens |
| Libraries: | humanC2H2ZF-ChIP Feb2015 1, JASPAR 2024 2 1 Najafabadi HS, Mnaimneh S, Schmitges FW, Garton M, Lam KN, Yang A, Albu M, Weirauch MT, Radovani E, Kim PM, Greenblatt J, Frey BJ, Hughes TR. C2H2 zinc finger proteins greatly expand the human regulatory lexicon. Nat Biotechnol 33:555-62 (2015). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | TF family: C2H2;BTB experiment: ChIP-seq/MEME/B1H-RC |
| Length: | 459 |
| Pfam Domains: | 23-125 BTB/POZ domain 359-379 Zinc-finger of C2H2 type 359-381 Zinc finger, C2H2 type 360-381 C2H2-type zinc finger 373-397 Zinc-finger double domain 387-409 C2H2-type zinc finger 387-409 Zinc finger, C2H2 type 405-426 Zinc-finger double domain 415-438 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MASGVEVLRFQLPGHEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRD 60 61 QFLLNPSSELQVSLMHSARIVADLLLSCYTGALEFAVRDIVNYLTAASYLQMEHVVEKCR 120 121 NALSQFIEPKIGLKEDGVSEASLVSSISATKSLLPPARTPKPAPKPPPPPPLPPPLLRPV 180 181 KLEFPLDEDLELKAEEEDEDEDEDVSDICIVKVESALEVAHRLKPPGGLGGGLGIGGSVG 240 241 GHLGELAQSSVPPSTVAPPQGVVKACYSLSEDAEGEGLLLIPGGRASVGATSGLVEAAAV 300 301 AMAARGAGGSLGAGGSRGPLPGGFSGGNPLKNIKCTKCPEVFQGVEKLVFHMRAQHFIFM 360 361 CPRCGKQFNHSSNLNRHMNVHRGVKSHSCGICGKCFTQKSTLHDHLNLHSGARPYRCSYC 420 421 DVRFAHKPAIRRHLKEQHGKTTAENVLEASVAEINVLIR |
| Interface Residues: | 139, 344, 345, 346, 347, 350, 354, 359, 369, 370, 371, 372, 373, 375, 376, 377, 397, 398, 399, 400, 401, 402, 403, 404, 405, 425, 426, 427, 428, 429, 430, 431, 432, 436 |
| 3D-footprint Homologues: | 3x1l_D, 8ssq_A, 5und_A, 8ssu_A, 6ml4_A, 5v3j_F, 5kkq_D, 5yel_A, 5ei9_F, 7eyi_G, 6wmi_A, 2i13_A, 6e94_A, 2kmk_A, 6jnm_A, 8cuc_F, 7y3l_A, 7n5w_A, 1tf3_A, 2gli_A, 7ysf_A, 1g2f_F, 5k5i_A, 1tf6_A, 7w1m_H, 1ubd_C, 4x9j_A, 2jpa_A, 8gn3_A, 1mey_C, 6blw_A, 2drp_D, 1f2i_J, 6u9q_A, 5kl3_A, 4m9v_C, 8h9h_G, 2lt7_A, 6a57_A, 3uk3_C, 1llm_D, 2wbs_A, 7txc_E, 7y3m_I, 5yj3_D, 5k5l_F |
| Binding Motifs: | ZBTB12_ChIP GTTCTAGAty MA1649.1 ryCTrGAACmy MA1649.2 CTrGAAC |
| Binding Sites: | MA1649.1.1 MA1649.1.10 / MA1649.1.11 / MA1649.1.8 / MA1649.1.9 MA1649.1.12 MA1649.1.13 MA1649.1.13 / MA1649.1.14 / MA1649.1.7 / MA1649.1.9 MA1649.1.15 / MA1649.1.16 MA1649.1.14 / MA1649.1.17 MA1649.1.18 MA1649.1.15 / MA1649.1.19 MA1649.1.1 / MA1649.1.2 MA1649.1.16 / MA1649.1.20 MA1649.1.3 MA1649.1.4 MA1649.1.5 MA1649.1.6 MA1649.1.6 / MA1649.1.7 MA1649.1.8 MA1649.1.10 MA1649.1.11 MA1649.1.17 MA1649.1.18 MA1649.1.19 MA1649.1.2 MA1649.1.20 MA1649.1.4 MA1649.2.1 / MA1649.2.16 MA1649.2.10 MA1649.2.11 / MA1649.2.3 MA1649.2.12 / MA1649.2.14 / MA1649.2.17 MA1649.2.13 / MA1649.2.7 MA1649.2.15 / MA1649.2.19 / MA1649.2.20 / MA1649.2.6 / MA1649.2.8 / MA1649.2.9 MA1649.2.18 MA1649.2.2 MA1649.2.4 MA1649.2.5 |
| Publications: | Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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