Transcription Factor
| Accessions: | P09066 (JASPAR 2024) |
| Names: | HME2_MOUSE, Homeobox protein en-2, Homeobox protein engrailed-2, Mo-En-2 |
| Organisms: | Mus musculus |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 324 |
| Pfam Domains: | 236-292 Homeobox domain 293-324 Engrailed homeobox C-terminal signature domain |
| Sequence: (in bold interface residues) | 1 MEEKDSKPSETAAEAQRQPEPSSGGGSGGGSSPSDSDTGRRRALMLPEVLQAPGNHQHPH 60 61 RITNFFIDNILRPEFGRRKDAGTCCAGAGGARGGEGGAGTTEGGGGGAGGAEQLLGARES 120 121 RPNPACAPSAGGTLSAAAGDPAVDGEGGSKTLSLHGGAKKPGDPGGSLDGVLKARGLGGG 180 181 DLSVSSDSDSSQASATLGAQPMLWPAWVYCTRYSDRPSSGPRSRKPKKKNPNKEDKRPRT 240 241 AFTAEQLQRLKAEFQTNRYLTEQRRQSLAQELSLNESQIKIWFQNKRAKIKKATGNKNTL 300 301 AVHLMAQGLYNHSTTAKEGKSDSE |
| Interface Residues: | 235, 236, 237, 238, 239, 277, 278, 280, 281, 284, 285, 288, 289, 292 |
| 3D-footprint Homologues: | 3d1n_M, 3cmy_A, 1nk2_P, 1fjl_B, 5zfz_A, 6fqp_B, 1ig7_A, 1puf_A, 6a8r_A, 2h1k_B, 1zq3_P, 3lnq_A, 1jgg_B, 6m3d_C, 2lkx_A, 2ld5_A, 2hdd_A, 7psx_B, 4cyc_A, 2r5y_A, 1b72_A, 5flv_I, 2hos_A, 7q3o_C, 5zjt_E, 2d5v_B, 5hod_A, 3a01_E, 5jlw_D, 3rkq_B, 1puf_B, 6es3_K, 4xrs_G, 1le8_A, 2xsd_C, 7xrc_C, 1e3o_C, 1au7_A, 1o4x_A, 4qtr_D, 1le8_B, 6fqq_E, 1du0_A, 4xrm_B, 1mnm_C, 8g87_X, 1k61_B |
| Binding Motifs: | PH0029.1 wgmmyYAATTRrygrah |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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