Transcription Factor
| Accessions: | HESX1 (HT-SELEX2 May2017), Q9UBX0 (JASPAR 2024) |
| Names: | ENSG00000163666, HESX1, hAnf, HESX1_HUMAN, Homeobox expressed in ES cells 1, Homeobox protein ANF |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1, JASPAR 2024 2 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q9UBX0 |
| Notes: | TF family: Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 2, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 2 |
| Length: | 185 |
| Pfam Domains: | 109-165 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MSPSLQEGAQLGENKPSTCSFSIERILGLDQKKDCVPLMKPHRPWADTCSSSGKDGNLCL 60 61 HVPNPPSGISFPSVVDHPMPEERASKYENYFSASERLSLKRELSWYRGRRPRTAFTQNQI 120 121 EVLENVFRVNCYPGIDIREDLAQKLNLEEDRIQIWFQNRRAKLKRSHRESQFLMAKKNFN 180 181 TNLLE |
| Interface Residues: | 109, 110, 111, 112, 150, 151, 153, 154, 157, 158, 161, 162, 165 |
| 3D-footprint Homologues: | 2h1k_B, 1fjl_B, 6a8r_A, 3cmy_A, 1ig7_A, 3d1n_M, 5zfz_A, 6fqp_B, 1puf_A, 5zjt_E, 6m3d_C, 3lnq_A, 2lkx_A, 1nk2_P, 1zq3_P, 1jgg_B, 2ld5_A, 3a01_E, 1au7_A, 5hod_A, 1puf_B, 2hdd_A, 7psx_B, 1b72_A, 5jlw_D, 3rkq_B, 2r5y_A, 6es3_K, 4xrs_G, 2hos_A, 7q3o_C, 4cyc_A, 2d5v_B, 5flv_I, 3l1p_A, 4j19_B, 1le8_A, 2xsd_C, 7xrc_C, 1e3o_C, 8g87_X, 4qtr_D, 1o4x_A, 1du0_A |
| Binding Motifs: | MA0894.1 gyTAATTrry HESX1_2 cyAATTrw HESX1_methyl_1 cyAATTrh MA0894.2 TAATTr |
| Publications: | Brickman JM, Clements M, Tyrell R, McNay D, Woods K, Warner J, Stewart A, Beddington RS, Dattani M. Molecular effects of novel mutations in Hesx1/HESX1 associated with human pituitary disorders. Development 128:5189-99 (2001). [Pubmed] |
| Related annotations: | PaperBLAST |
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