Transcription Factor

						

			
Accessions: Q9QY61 (JASPAR 2024)

			
Names: Homeodomain protein IRXA3, Iroquois homeobox protein 4, Iroquois-class homeodomain protein IRX-4, IRX4_MOUSE
Organisms: Mus musculus
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 515
Pfam Domains:   146-203 Homeobox domain
  161-200 Homeobox KN domain
Sequence: 
(in bold interface residues)		   1 MSYPQFGYPYSSAPQFLMTTNSLSTCCESGGRTLADSGPAASAQAPVYCPVYESRLLATA   60
  61 RHELNSAAALGVYGSPYGSSQGYGNYVTYGSEASAFYSLNSFESKDGTGSSHAGLPPTAA  120
 121 AAYYPYEPALSQYPYDRYGTVDSGTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLA  180
 181 IITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCADEKRPYGEGEEEEAGEEESREEPL  240
 241 KSAKSEGHAGKDDKELELSDLEDFDPLDAETSECELKTPFQSLDSGPERIPASSDGPGTG  300
 301 KEASTTLRMPLGTAGGAVMDGDLERARNCLRSTVVVPDSGAEGGPPACEAKLTFAQAGAP  360
 361 PNLETKPRIWSLAHTATAAAATALSQTEFPSCMLKRQGPTGVSATTPASSPAVTAPSGAL  420
 421 DRHQDSPVTSLRNWVDGVFHDPILRHSTLNQAWATAKGALLDPGPLGRNLGAGTNVLTTP  480
 481 LACSFPPTVPQDVPPAGASRELLATPKAGGKPFCT
Interface Residues: 146, 147, 148, 149, 150, 154, 188, 189, 191, 192, 195, 196, 197, 199, 200, 202, 203
3D-footprint Homologues: 1puf_A, 6fqp_B, 1fjl_B, 5jlw_D, 3cmy_A, 1puf_B, 1ig7_A, 5zjt_E, 3d1n_M, 2hdd_A, 1nk2_P, 2r5y_A, 4cyc_A, 2lkx_A, 1zq3_P, 2ld5_A, 4xrs_G, 3rkq_B, 2h1k_B, 1mnm_C, 7psx_B, 4xrm_B, 1b72_A, 1k61_B, 1o4x_A, 1du0_A, 5flv_I, 3a01_E, 2d5v_B, 1le8_B, 6fqq_E, 2hos_A
Binding Motifs: PH0085.1 wawrwACATGTwawwcw
			
Publications: Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
Disclaimer and license


These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.