Transcription Factor

Accessions: P14652 (JASPAR 2024)
Names: Homeobox protein Hox-2.8, Homeobox protein Hox-2H, Homeobox protein Hox-B2, HXB2_HUMAN, K8
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: P14652
Length: 356
Pfam Domains: 144-200 Homeobox domain
Sequence:
(in bold interface residues)
1 MNFEFEREIGFINSQPSLAECLTSFPAVLETFQTSSIKESTLIPPPPPFEQTFPSLQPGA 60
61 STLQRPRSQKRAEDGPALPPPPPPPLPAAPPAPEFPWMKEKKSAKKPSQSATSPSPAASA 120
121 VPASGVGSPADGLGLPEAGGGGARRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALL 180
181 DLTERQVKVWFQNRRMKHKRQTQHREPPDGEPACPGALEDICDPAEEPAASPGGPSASRA 240
241 AWEACCHPPEVVPGALSADPRPLAVRLEGAGASSPGCALRGAGGLEPGPLPEDVFSGRQD 300
301 SPFLPDLNFFAADSCLQLSGGLSPSLQGSLDSPVPFSEEELDFFTSTLCAIDLQFP
Interface Residues: 144, 145, 146, 147, 185, 186, 188, 189, 192, 193, 196, 197, 200
3D-footprint Homologues: 6a8r_A, 2h1k_B, 1puf_A, 3cmy_A, 5zfz_A, 1fjl_B, 3lnq_A, 1jgg_B, 2lkx_A, 6m3d_C, 1nk2_P, 1zq3_P, 2ld5_A, 7q3o_C, 6es3_K, 1ig7_A, 7psx_B, 5hod_A, 3a01_E, 5jlw_D, 3rkq_B, 4xrs_G, 2hdd_A, 4cyc_A, 2r5y_A, 1puf_B, 5flv_I, 2hos_A, 1b72_A, 5zjt_E, 4j19_B, 1e3o_C, 1le8_A, 7xrc_C, 1au7_A, 2xsd_C, 1o4x_A, 1du0_A, 4qtr_D, 3l1p_A, 8g87_X
Binding Motifs: MA0902.1 rstmATTArc
UN0565.1 rGGTGTTAATkr
MA0902.2 symATTAs
MA0902.3 ymATTA
UN0565.2 rGGTGTTAATk
Publications: Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]
Related annotations: PaperBLAST

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