Transcription Factor
| Accessions: | CEBPD_DBD (HumanTF 1.0), CEBPD_TF2 (HumanTF2 1.0), CEBPD (HT-SELEX2 May2017) |
| Names: | CEBPD, Q504X4_HUMAN, ENSG00000221869 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2, HT-SELEX2 May2017 3 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] 3 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | Q504X4 |
| Notes: | Ensembl ID: ENSG00000221869; DNA-binding domain sequence; TF family: bZIP; Clone source: Gene synthesis, Ensembl ID: ENSG00000221869; Construct type: TF2(3xFLAG); TF family: bZIP; Clone source: Jolma et al. 2013, TF family: bZIP experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: bZIP experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4 |
| Length: | 93 |
| Pfam Domains: | 18-69 Basic region leucine zipper 23-74 bZIP transcription factor |
| Sequence: (in bold interface residues) | 1 PGPAREKSAGKRGPDRGSPEYRQRRERNNIAVRKSRDKAKRRNQEMQQKLVELSAENEKL 60 61 HQRVEQLTRDLAGLRQFFKQLPSPPFLPAAGTA |
| Interface Residues: | 25, 28, 29, 31, 32, 35, 36, 50, 63 |
| 3D-footprint Homologues: | 1nwq_C, 6mg1_B, 2dgc_A, 5t01_B, 2c9l_Z, 7yq3_E |
| Binding Motifs: | CEBPD_DBD rTTrCGCAAy ATF4_CEBPD rgaTGAyGCAAyms ERF_CEBPD rsmGGAwrTTGCGyAAy ETV2_CEBPD rsCGGAwrTTrCGyAAy ETV5_CEBPD rsCGGAwrTTGCGyAAy FLI1_CEBPD rmmGGAwATTGCGcAAy TEAD4_CEBPD_1 rgwATgygrTTrCGyAAy TEAD4_CEBPD_2 rTTrCGCAAymcymwahGgAATGy TEAD4_CEBPD_2_3 rTTrCGCAAymmcktwrgwATGy TEAD4_CEBPD_2_3_4 rTTrCGyAAyayhwwggwATky CEBPD_2 brTTGCGyAAys CEBPD_methyl_1 trTTGCGyAAyr |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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