Transcription Factor
| Accessions: | BATF (HT-SELEX2 May2017), BATF_HUMAN (HOCOMOCO 10), Q16520 (JASPAR 2024) |
| Names: | BATF, ENSG00000156127, B-ATF, B-cell-activating transcription factor, Basic leucine zipper transcriptional factor ATF-like, BATF_HUMAN, SF-HT-activated gene 2 protein, SFA-2 |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1, HOCOMOCO 10 2, JASPAR 2024 3 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] 2 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q16520 |
| Notes: | TF family: bZIP experiment: HT-SELEX Hamming distance: 1 cycle: 3b0, TF family: bZIP experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3b0 |
| Length: | 125 |
| Pfam Domains: | 27-83 bZIP transcription factor 28-78 Basic region leucine zipper |
| Sequence: (in bold interface residues) | 1 MPHSSDSSDSSFSRSPPPGKQDSSDDVRRVQRREKNRIAAQKSRQRQTQKADTLHLESED 60 61 LEKQNAALRKEIKQLTEELKYFTSVLNSHEPLCSVLAASTPSPPEVVYSAHAFHQPHVSS 120 121 PRFQP |
| Interface Residues: | 32, 33, 36, 37, 39, 40, 43, 44, 47 |
| 3D-footprint Homologues: | 1skn_P, 2wt7_A, 7x5e_F, 6mg1_B, 1nwq_C, 5vpe_D, 1dh3_C, 5t01_B |
| Binding Motifs: | MA0462.1 rrwATGAsTCA BATF_2 gmayGaCACg BATF_methyl_1 smayGaCACg BATF_HUMAN.H10MO.A|M01030 asTyyyrwwwTGAsTcAk MA0462.2 waTGACTCAth MA1634.1 waTGACTCAth MA0462.3 TGACTCA MA1634.2 TGACTCA |
| Binding Sites: | MA1634.2.2 MA0462.3.1 / MA0462.3.12 / MA0462.3.13 / MA0462.3.14 / MA0462.3.16 / MA0462.3.18 / MA0462.3.2 / MA0462.3.4 / MA1634.2.11 / MA1634.2.17 / MA1634.2.19 / MA1634.2.3 / MA1634.2.5 / MA1634.2.6 / MA1634.2.7 / MA1634.2.8 / MA1634.2.9 MA0462.3.3 / MA0462.3.5 / MA0462.3.6 / MA0462.3.7 / MA0462.3.8 / MA0462.3.9 MA0462.3.20 / MA1634.2.14 MA0462.3.11 / MA0462.3.15 / MA0462.3.17 MA0462.3.19 / MA1634.2.15 MA0462.1.1 MA0462.1.10 MA0462.1.11 MA0462.1.12 MA0462.1.13 MA0462.1.14 MA0462.1.15 MA0462.1.16 MA0462.1.17 MA0462.1.18 / MA0462.1.19 MA0462.1.2 MA0462.1.20 MA0462.1.3 MA0462.1.4 MA0462.1.5 MA0462.1.6 MA0462.1.7 MA0462.1.8 MA0462.1.9 MA0462.3.10 / MA1634.2.10 / MA1634.2.16 MA0462.2.1 MA0462.2.10 / MA0462.2.5 MA0462.2.11 / MA0462.2.6 MA0462.2.12 MA0462.2.13 MA0462.2.14 MA0462.2.15 / MA0462.2.7 MA0462.2.16 MA0462.2.17 / MA0462.2.8 MA0462.2.18 MA0462.2.19 / MA0462.2.9 MA0462.2.1 / MA0462.2.2 MA0462.2.10 / MA0462.2.20 MA0462.2.2 / MA0462.2.3 MA0462.2.4 MA0462.2.3 / MA0462.2.5 MA0462.2.6 MA0462.2.4 / MA0462.2.7 MA0462.2.8 MA0462.2.9 MA1634.1.19 MA1634.1.20 MA1634.1.1 MA1634.1.10 / MA1634.1.7 MA1634.1.11 MA1634.1.12 / MA1634.1.8 MA1634.1.13 MA1634.1.14 / MA1634.1.9 MA1634.1.15 MA1634.1.10 / MA1634.1.16 MA1634.1.17 MA1634.1.18 MA1634.1.11 / MA1634.1.19 MA1634.1.2 MA1634.1.13 / MA1634.1.20 MA1634.1.3 MA1634.1.3 / MA1634.1.4 MA1634.1.5 MA1634.1.5 / MA1634.1.6 MA1634.1.7 MA1634.1.6 / MA1634.1.8 MA1634.1.9 MA0462.2.11 MA0462.2.12 MA0462.2.13 MA0462.2.14 MA0462.2.15 MA0462.2.16 MA0462.2.17 MA0462.2.18 MA0462.2.19 MA0462.2.20 MA1634.1.4 MA1634.1.12 MA1634.1.14 MA1634.1.15 MA1634.1.16 MA1634.1.17 MA1634.1.18 MA1634.1.2 MA1634.2.1 / MA1634.2.13 / MA1634.2.4 MA1634.2.20 MA1634.2.12 MA1634.2.18 |
| Publications: | Li P, Spolski R, Liao W, Wang L, Murphy TL, Murphy KM, Leonard WJ. BATF-JUN is critical for IRF4-mediated transcription in T cells. Nature 490:543-6 (2012). [Pubmed] Schleussner N, Merkel O, Costanza M, Liang HC, Hummel F, Romagnani C, Durek P, Anagnostopoulos I, Hummel M, Jöhrens K, Niedobitek A, Griffin PR, Piva R, Sczakiel HL, Woessmann W, Damm-Welk C, Hinze C, Stoiber D, Gillissen B, Turner SD, Kaergel E, von Hoff L, Grau M, Lenz G, Dörken B, Scheidereit C, Kenner L, Janz M, Mathas S. The AP-1-BATF and -BATF3 module is essential for growth, survival and TH17/ILC3 skewing of anaplastic large cell lymphoma. Leukemia 32:1994-2007 (2018). [Pubmed] |
| Related annotations: | PaperBLAST |
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