Transcription Factor
| Accessions: | MEIS1_HUMAN (HOCOMOCO 10), O00470 (JASPAR 2024) |
| Names: | MEIS1_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 390 |
| Pfam Domains: | 275-329 Homeobox domain 290-329 Homeobox KN domain |
| Sequence: (in bold interface residues) | 1 MAQRYDDLPHYGGMDGVGIPSTMYGDPHAARSMQPVHHLNHGPPLHSHQYPHTAHTNAMA 60 61 PSMGSSVNDALKRDKDAIYGHPLFPLLALIFEKCELATCTPREPGVAGGDVCSSESFNED 120 121 IAVFAKQIRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGK 180 181 MPIDLVIDDREGGSKSDSEDITRSANLTDQPSWNRDHDDTASTRSGGTPGPSSGGHTSHS 240 241 GDNSSEQGDGLDNSVASPSTGDDDDPDKDKKRHKKRGIFPKVATNIMRAWLFQHLTHPYP 300 301 SEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGTPYNPDGQPMGGFVM 360 361 DGQQHMGIRAPGPMSGMGMNMGMEGQWHYM |
| Interface Residues: | 273, 275, 276, 320, 321, 324, 325, 326, 328, 329 |
| 3D-footprint Homologues: | 6fqp_B, 2d5v_B, 1puf_B, 4j19_B, 7q3o_C, 1le8_A, 5hod_A, 6fqq_E, 1le8_B, 5zfz_A, 3cmy_A, 1fjl_B, 4xrm_B, 1mnm_C, 6a8r_A, 3lnq_A, 1k61_B, 4xrs_G, 3rkq_B |
| Binding Motifs: | MA0498.2 wTGACAg UN0570.1 TGTCAATTA- MEIS1_HUMAN.H10MO.C|M01323 TGACAGbTTwahg MA1639.1 rhcATmAATCAww MA0498.3 TGACA MA1639.2 cATmAATCA |
| Binding Sites: | MA1639.1.1 MA1639.1.10 MA1639.1.11 MA1639.1.12 MA1639.1.13 MA1639.1.14 / MA1639.1.6 MA1639.1.15 / MA1639.1.7 MA1639.1.16 MA1639.1.17 MA1639.1.18 MA1639.1.19 MA1639.1.2 MA1639.1.20 MA1639.1.3 MA1639.1.4 MA1639.1.1 / MA1639.1.5 MA1639.1.6 MA1639.1.2 / MA1639.1.7 MA1639.1.3 / MA1639.1.8 MA1639.1.4 / MA1639.1.9 MA1639.1.10 MA1639.1.11 MA1639.1.12 MA1639.1.13 MA1639.1.14 MA1639.1.15 MA1639.1.16 MA1639.1.17 MA1639.1.18 MA1639.1.19 MA1639.1.20 MA1639.1.5 MA1639.1.8 MA1639.1.9 MA1639.2.6 MA1639.2.13 / MA1639.2.17 / MA1639.2.9 MA1639.2.8 MA1639.2.1 MA1639.2.10 MA1639.2.11 / MA1639.2.12 / MA1639.2.20 MA1639.2.14 MA1639.2.15 / MA1639.2.2 MA1639.2.16 MA1639.2.18 / MA1639.2.19 MA1639.2.3 MA1639.2.4 MA1639.2.5 MA1639.2.7 |
| Publications: | Knoepfler P. S., Calvo K. R., Chen H., Antonarakis S. E., Kamps M. P. Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1. Proc. Natl. Acad. Sci. USA 94:14553-14558 (1997). [Pubmed] Penkov D, Mateos San Martín D, Fernandez-Díaz LC, Rosselló CA, Torroja C, Sánchez-Cabo F, Warnatz HJ, Sultan M, Yaspo ML, Gabrieli A, Tkachuk V, Brendolan A, Blasi F, Torres M. Analysis of the DNA-binding profile and function of TALE homeoproteins reveals their specialization and specific interactions with Hox genes/proteins. Cell Rep 3:1321-33 (2013). [Pubmed] |
| Related annotations: | PaperBLAST |
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